Process Development Scientist (Drug Substance Technologies)
HOW MIGHT YOU DEFY IMAGINATION?
Youve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge youve worked hard to acquire and the passion you already have. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.Live
What you will do
Lets do this! Lets change the world!
Amgens Process Development organization is seeking a Scientist (Lvl 5B) to join the Pre-Pivotal Drug Substance Technologies organization and be responsible for developing innovative solutions to drive our small molecule pipeline. The scientist will be involved in the dynamic transition of new programs / molecular targets from Discovery Chemistry, into the clinical development space, and through Clinical Proof of Concept (Early Phase Chemical Development). The scientist will be primarily involved in the use of innovative process technologies to drive route selection activities and the development of chemical processes to be utilized in the manufacture of Drug Substance to help drive our growing and dynamic Small Molecule Portfolio.Scientific/Technical Responsibilities
Develops technology to manufacture drug candidates in a practical, efficient, and safe manner.
Champions innovative applications of technology [High Throughput Experimentation, Biocatalysis, Flow chemistry, process analytical technologies (PAT)] to solve challenging synthetic problems and drive improvements in sustainability, process efficiency, safety, and cost of goods.
Provides significant contributions to drug substance development teams (e.g., product and process development teams, product quality teams) by providing drug substance updates, documentation, data interpretation, technical recommendations, etc.
Serves as a technical expert and keeps current in organic chemistry and applications of process technology in pharmaceutical development including literature and technology development.
Improves the technical or scientific capabilities of the department and routinely answers questions on or resolves scientific/technical issues.
Collaborates in cross-functional teams to develop Amgens pipeline.
Works cross-functionally to deliver regulatory documents and supporting documentation in support of Amgens regulatory filings.
Delivers processes amenable to manufacturing operations and carry out deliveries of drug substance in a cGMP manufacturing environment.
Ability and desire to lead synthetic route development, drive new technology development, and eventually program management.
Effectively participates on drug substance development teams as a team member.
Works effectively in a multi-disciplinary team of chemists, engineers and attribute scientists.
Collaborates with other scientists and professionals outside the department.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The vital attribute professional we seek will have these qualifications.Basic Qualifications
Doctorate degree or Doctorate degree by December 2021
Masters degree and 4 years of scientific experience
Bachelors degree and 6 years of scientific experiencePreferred Qualifications
Doctorate degree in Organic Chemistry, Medicinal Chemistry or Synthetic Chemistry
Post-doctoral research experience
Track record of demonstrated scientific accomplishments in the field of organic chemistry
Ability to champion new technologies
Experience in the pharmaceutical / biotech or related industry that includes participation and contribution to scientific project teams
Familiarity with common industrial unit operations including crystallization (batch and continuous mode), filtration and drying
Familiarity with the use of design of experiments (DoE) and Process Analytical Technology (PAT) techniques
Familiarity with laboratory automation, data analysis and visualization techniques and tools
Familiarity with Environmental Health and Safety expectations for chemical laboratories
Familiarity with current Good Manufacturing Practices for preparing drug substances and intermediates
Demonstrated ability to effectively work in a fast-paced team environment
Excellent interpersonal, presentation, written and verbal skills
Knowledge of basic office and chemistry software including Microsoft Word, Excel, PowerPoint, ChemDraw, and SciFinder
Some of the vast rewards of working here
As we work to develop treatments that take care of others, so we work to care for our teammates professional and personal growth and well-being.
Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor
Objects in your future are closer than they appear. Join us.
#operations21Equal Opportunity Statement
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.
Join UsIf you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.