Principal Scientist I, In Vivo Pharmacology
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
We are hiring a Principal Scientist I to join the In Vivo Pharmacology Department in Oncology Discovery at Abbvie. The Principal Scientist I will conduct tumor efficacy and PK/PD studies, develop novel preclinical models and provide pharmacology support to innovative cancer drug development. The scientist will report to Director, Preclinical Pharmacology and work collaboratively in a project team setting with biology, medicinal chemistry and DMPK scientists, providing in vivo proof-of-principle for target discovery and validation, formulating and executing efficient in vivo structure activity relationship strategy and advancing oncology programs to clinical development.
General Position Summary/Purpose:
Provide preclinical Pharmacology support to Abbvie oncology drug discovery and development projects in targeted therapeutics and immuno-oncology. Conceive and implement novel experimental approaches to tumor model development, efficacy/PK/PD, in vivo mechanism-of-action investigation, target discovery and validation, disease mechanisms, resistance biology, and tumor microenvironment interaction in support of drug discovery and development. Investigate, develop, validate or optimize existing and new methods/models to solve project related scientific problems. Work closely with scientists in biology, medicinal chemistry, DMPK, translational medicine while reporting to Director, Preclinical Pharmacology. Generate efficacy and PD data to support preclinical development of drug candidates and regulatory submissions. Develop productive collaborations and communications with other groups across scientific disciplines.
Key Accountabilities/Core Job Responsibilities:
- Design and conduct tumor efficacy, imaging and PD studies to support in vivo POC, SAR and IND submission.
- Provide Pharmacology knowledge and strategy within project team structure and present/report analyses of in vivo studies.
- Understand and adhere to IACUC protocols regarding animal welfare and handling.
- Cell culture, sorting and genetic manipulation of cells to support efficacy studies and tumor model development.
- Conduct ex vivo assays such as multi-color FACS, MSD, WES and Luminex to understand MOA of in vivo studies.
- Develop novel preclinical models such as genetically modified mouse models, orthotopic tumor models, adoptive transfer and humanized models
- Improve existing Pharmacology workflows, data visualization tools, and work across discovery teams to integrate efficient workflows for cross-functional analyses and endpoints.
- Thinking critically and innovatively.
- Commitment to scientific rigor, high data quality and careful documentation.
- Self-motivated, possess strong problem solving and organizational skills.
- Ability to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment.
- Excellent written and verbal communication skills.
- Flexibility and motivation to learn techniques and accomplish goals outside those stated above.
- PhD in pharmacology, cancer biology, cell biology, immunology, or related field with 8+ years of drug development experience in a pharmaceutical or biotech industry setting, and a solid publication record.
- A strong background in pharmacology, cancer biology or immunology.
- Demonstrated aptitude for innovation using novel/emerging technologies.
- Experience in designing and interpreting IND-enabling in vivo PK/PD/efficacy studies and report writing
- Proficient hands-on experience with mouse tumor models.
- Experience and knowledge with genetically engineered mouse models and orthotopic tumor models
- Mouse surgery and in vivo imaging experience is desired.
- Technical experience in flow cytometry, primary cell culture, tissue processing, as well as other standard molecular and cellular biology assays (MSD, ELISA, Wes, etc.).
- Must be proactive and able to work effectively on multiple projects in a fast-paced, dynamic environment.
- Strong written and verbal communication skills.
- Demonstrated ability to work independently and collaboratively to design, execute and interpret experiments to answer scientific questions (desired).
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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.