Temporary, Research Associate III

Department: Research
Location: Richmond, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. At Sangamo, we are passionate in developing genomic medicines to transform the lives of patients with serious diseases. We transform lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our team. Let’s build a better future together.

JOB SUMMARY:   

Sangamo Therapeutics is seeking a talented research associate for a new temporary position in our Neuroscience group to support the development of novel ZFP-TFs for the treatment of CNS diseases.

The successful candidate will work within the Neuroscience team and contribute to the development of novel CNS therapeutics. Key responsibilities will include performance of neuronal cell culture experiments to demonstrate target engagement and support lead candidate selection, screening and assay development, and generation of data from in vivo studies to support advancement of CNS programs. The position requires adaptability, creativity, good written and verbal communication skills, as well as a capacity for constant innovation in pursuit of company goals. The environment is exciting and fast-paced, and offers the opportunity to work and publish at the cutting edge of genome engineering research and translational medicine.

ESSENTIAL FUNCTIONS: 

• Perform in vitro experiments in primary and iPSC-derived neurons
• Perform chronic AAV expression studies in mammalian cell models
• Process animal tissue for RNA, DNA, and protein endpoints
• Successfully plan, execute, and document laboratory procedures and experiments with great attention to detail
   

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• B.S. or M.S. in molecular and/or cellular biology, biochemistry, neuroscience, bioengineering, chemical engineering, or related discipline
• 4+ years of relevant laboratory experience in an academic research laboratory or biotechnology company
• Experience with neuronal cell culture, including AAV and nucleic acid transfection
• Extensive experience with molecular biology and biochemical methods and techniques including RT-qPCR, ELISA, western blotting, and nucleic acid and protein isolation from mammalian cells and animal tissues
• Preferred candidates will be proficient in use of the Microsoft Office Suite and statistical analysis and graphing software (e.g. GraphPad Prism, SigmaPlot)

OTHER QUALIFICATIONS:

• Strong experiment design, problem-solving, and data analysis skills are desired
• Excellent communication and presentation skills
• Experience with high-throughput assays preferred
• Experience with gene therapy and CNS-related fields preferred

Sangamo is an equal opportunity employer

The above reflects management’s definition of essential functions for this position but does not restrict the tasks that may be assigned.

The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.

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