Senior Scientist Next Generation Sequencing

Employer
Sanofi US
Location
01701, Framingham
Posted
Jun 11, 2021
Ref
R2597049
Required Education
Masters Degree/MBA
Position Type
Full time

We are seeking a motivated Senior Scientist to join the newly formed Next Generation Sequencing (NGS) Core group to support genomic analyses of multiple therapeutic modalities within the Genomic Medicine Unit (GMU) CMC organization. The role is responsible for strategically leading projects, interfaced within a cross-functional team, to develop and implement genomic analytical solutions for programs spanning precandidate selection through commercialization. The ideal candidate will be expected to support end-to-end NGS solutions, through wet-lab method development to analytical pipeline design and execution.

Key Responsibilities:

  • Develop NGS sample preparation methods to characterize and release various biopharmaceutical candidates including monoclonal antibodies, viral vectors for gene therapy, and cell lines.

  • Lead project teams comprised from analytical and data sciences groups to develop and implement genomic analytical solutions for programs spanning precandidate selection through commercialization.

  • Develop and execute complex molecular biology protocols, specifically various NGS-based library preparation and characterization protocols, using established molecular biology techniques and novel solutions.

  • Develop and execute NGS analysis pipelines for execution in a cloud-based computational environment.

  • Lead and implement technology development to accelerate NGS workflows.

  • Potentially manage and lead a team of scientists including the coordination of workload across the group.

  • Communicate with internal stakeholders to provide develop customs analysis solutions and provide troubleshooting support.

  • Provide technical support to existing solutions. 

  • Keep records of development work and testing in a GxP environment utilizing electronic notebook solutions.

  • Write publications for scientific journals.

  • Represent the group at external conferences.

Basic Qualifications:

  • Ph.D. in a relevant discipline with a minimum of 4 years of relevant industry experience or a Master’s degree with a minimum of 8 years of relevant industry experience or Bachelor’s degree with a minimum of 10 years of relevant industry experience.

  • Minimum of 2 years’ experience with NGS, spanning DNA extraction through sample analysis.

  • Expertise with basic molecular biology techniques (i.e., ligation, PCR, and qPCR) as well as nucleic acid extraction and analysis techniques (i.e., Nanodrop, DNA fragment analyzers, ddPCR, etc.).

  • Expertise in bioinformation with a working understanding of genomic analysis solutions (i.e., FastQC, Bowtie2, SAMtools, NCBI BLAST+, etc.).

  • Scripting experience in coding languages (i.e., bash, awk, python, R, etc.).

  • Expertise in setting up clod-based solutions to host and execute NGS analysis pipelines.

  • Advanced understanding of NGS platforms, specifically those utilizing the synthesis by sequencing technique (i.e., Illumina platforms).

  • Familiarity with custom software validation regulations.

  • Proven experience and ability to lead projects within a cross functional team.

  • Track record of publications in high quality journals.

  • Ability to work independently and adapt under aggressive and/or changing timelines.

Preferred Qualifications:

  • Familiarity with liquid handlers and other automation tools.

  • Previous management experience is highly preferred.

  • Knowledge of and experience with other sequencing platforms (i.e., PacBio Sequel II) is highly preferred.

  • Prior experience in leading the internalization of custom NGS analysis pipelines is highly preferred.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.