Scientist I/II - Bioassay Development
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Since 2013, AbbVie has expanded its commitment to the San Francisco Bay Area, now represented by three facilities in Redwood City, South San Francisco, Sunnyvale and a future new Bay Area headquarters in South San Francisco. AbbVie employees in the Bay Area drive AbbVie’s research-based, innovation driven missions in healthcare. Specifically, Bay Area employees bring deep scientific expertise and commercial excellence to advance cancer care. Current oncology areas of focus include immuno-oncology, tumor targeting, tumor dependency and precision medicine. With facilities positioned in the heart of the biotechnology industry, we are able to collaborate with the best and brightest minds in oncology.
POSITION DESCRIPTION SUMMARY:
We are seeking a Scientist I/II to join our Bioassay Development team. This Scientist I/II will support the development and evaluation of newly discovered oncology drugs and existing clinical candidates. This role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs. In this role you will have unique exposure to a significant breadth and depth of drug development experience, numerous cross-functional interactions, and opportunities to grow and develop in your scientific career.
In this lab-based role, your major responsibilities will include the development and optimization of novel cell-based potency assays (bioassays) and target-binding potency assays critical to the development of new oncology biologic drugs, including therapeutic antibodies, antibody variants, and antibody drug conjugates (ADCs). You will interact cross-functionally with teams from Discovery, CMC, QC, and more. You will also perform potency testing and biological activity characterization to support drug development activities and IND submissions. As a potency assay subject matter expert (SME), you will have opportunities to train team members, perform complex troubleshooting and optimization experiments, and present your work to various cross-functional teams.
- Bachelor’s Degree in biology, cell/molecular biology, or a related field with typically 5-7 years of applicable industry experience, or Master’s Degree in biology, cell/molecular biology, or a related field with typically 2-5 years of applicable industry experience.
- Strong enthusiasm to independently innovate and develop creative solutions for complex problems
- Hands on experience in the development of the ligand binding assays and/or cell-based potency assays, ideally from conception to completion.
- Direct experience with potency assay optimization and troubleshooting is a plus.
- Experience with mammalian cell culture and use of cells in cell-based assays
- Experience using PRISM, PLA, Softmax Pro, or similar data analysis software.
- Strong verbal and written communication skills.
- Demonstrated abilities to quickly learn new skills, think independently, and work collaboratively in teams.
- The ideal candidate will be hard-working, self-motivated, detail-oriented, highly organized, and able to adapt quickly to changes.
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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.