Associate Medical Director/Medical Director

Calcilytix Therapeutics, a subsidiary of BridgeBio Pharma, is developing CLTX-305 (encaleret), a negative allosteric modulator of the calcium-sensing receptor (CaSR) for the treatment of Autosomal Dominant Hypocalcemia Type 1 (a genetic cause of hypoparathyroidism due to gain-of-function mutations in CaSR) and acquired hypoparathyroidism (usually secondary to prior neck surgery). The program is currently in Phase 2 for both indications.

BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. 

To learn more, visit us at https://bridgebio.com

Who You Are:

Calcilytix Therapeutics is looking for a talented and highly self-motivated Clinician/Scientist to join our team. This position will have complete responsibility for the planning, implementation, and daily operation of all functions and projects in Medical Affairs. In addition, this individual will collaborate with key internal and external stakeholders to support company initiatives that improve the quality and content of all relevant medical and research programs. If you are a person who enjoys creating new Medical Affairs functions and services from the “ground up,” this may be a very well-suited job opportunity for you!

Responsibilities:

• Develop relationships with a wide range of relevant and disease-specific health care professionals, providing them with credible, fair, balanced, scientific information about Calcilytix Therapeutics current and future drug products, research activities, and future product developments, as apropos
• Be a primary source of fair-balanced medical information for HCPs and be trained and able to manage and address any and all unsolicited questions about the safety and use of current and future drug products based on the available scientific data
• Ideally, be a therapeutic area expert in rare disease/orphan drug development programs, emphasizing disorders related to bone metabolism or calcium homeostasis
• Lead the regular review of relevant literature, participate in scientific congresses and conferences, and develop a granular understanding of the diagnostic algorithm and patient journey
• Play a role in internal training and knowledge sharing, including KOL and site profiling
• Be responsible for the identification of potential investigators and research projects; may include assistance with the investigator-sponsored trial process, sponsored study site identification, recruitment strategies, development of resources for field use, and collaboration with clinical operations
• The above job description documents the general nature and level of work but is not intended to be an exhaustive list of activities, duties, and responsibilities require of job incumbents.  Therefore, job incumbents are expected to perform all other duties as assigned or required, as training and experience allow

Education, Experience & Skills Requirements:

• MD, Ph.D., PharmD, RN, or NP with clinical practice experience is required
• A background or experience in endocrinology, nephrology, or any focused experience in orphan diseases is highly desirable
• Minimum of 3-4+ years in as Medical Science Liaison (MSL) or home office/field-based Medical Affairs experience
• Excellent interpersonal communication and presentation skills (including the ability to network)
• Able to participate in a scientific dialogue with KOL’s and researchers
• Excellent teaching skills and ability to present and discuss scientific material clearly and concisely
• Proven ability to create and sustain relationships with industry leaders
• Skilled in clinical research and an understanding of the process of pharmaceutical product development and approval
• Demonstrated ability to organize, prioritize and work effectively with minimal supervision in a constantly changing environment
• Able to function in a highly regulated environment and to adhere to all company/corporate guidelines and standard operating procedures (SOP’s) while responding to a variety of questions and requests from health care professionals
• Ability to work independently and to converse on a peer to peer basis with HCPs
• Pharma experience in endocrinology or nephrology therapeutic areas is a plus, as well as experience in orphan / rare diseases of any kind
• Thorough knowledge of US/ex-US healthcare systems, disease management, and medical research
• Ability to understand and summarize clinical trial reports and papers.  Ability to research scientific literature and write reports, papers, and research protocols
• Solid understanding of GCP and ICH guidelines. Current working knowledge of US legal, regulatory, and compliance regulations and guidelines relevant to industry interactions with health- care professionals
• Critical thinking
• Ability to handle objections and manage issues presented by HCPs
• Ability to effectively work, function, and contribute with cross-functional teams
• Proven ability to use IT tools and interface effectively with a wide variety of technical platforms

What We Offer:

• Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
• A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
• Learning and development training to help employees be the best version of themselves
• Collaborative business environment
• Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
• Excellent benefits package
• Flexible PTO
• With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
• A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
• Work with the most productive groups of R&D operators in the industry
• Partnerships with leading institutions
• A platform for meaningful scientific contributions to shine
• Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.