Associate Director, Immuno Oncology

Employer
PMV Pharma
Location
We are currently in Cranbury, NJ but will soon be relocating to Princeton, NJ
Salary
salary, bonus, equity, very generous medical coverage and PTO
Posted
Jun 09, 2021
Required Education
Doctorate/PHD/MD
Position Type
Full time

Responsibilities

  • Lead an immuno-oncology group at PMV to capitalize on observations of immune cell activation following reactivation of mutant p53 
  • Design and execution of mechanism of action studies including optimization of in-house assays
  • Validation of future p53-related immune cell interacting targets to support drug development program initiation
  • Supervision of research associates 
  • Participation in project teams to establish and influence immuno-oncology project strategy and planning and to provide scientific insight. 

Requirements

  • PhD with at least 5+ years of expertise in the field of cancer immunology
  • Previous industry experience in immuno-oncology drug development is preferred
  • In-depth knowledge of immune cell biology and significant experience with in vitro and in vivo immuno-phenotyping. 
  • Working knowledge of in vivo models utilized in immuno-oncology
  • Experience with tumor associated immune cell-based functional assays (activation, differentiation, proliferation, suppression, target cell killing), cytokine analysis, primary cell isolation, molecular biology (ELISA, qRT-PCR, Western analysis) and tissue culture techniques
  • Expertise in designing multi-color flow cytometry and interpretation
  • Strong track record in target identification/validation using small-molecule inhibitors and/or genetic manipulation (shRNA, CRISPR)
  • A thorough knowledge of the molecular pathways involved in the activation of the tumor immune response, knowledge of the p53 pathway a plus
  • Ability to work in alignment with PMV and manager to independently drive research projects to design, plan, execute and interpret experiments
  • Proven track record of successful scientific accomplishments, presentations and/or peer reviewed publications in field of immuno-oncology

Attributes

  • Outstanding scientific capabilities to design, execute and interpret key experiments
  • Excellent communication and presentation skills, ability to present results in multiple forums
  • Experience in a supervisory role is preferred
  • Ability to be productive and successful in a fast-paced work environment
  • Independent and motivated team player able to work closely with others to solve complex problems