Pilot Process Development Associate, Downstream (contract)

Location
Redwood City, CA
Posted
Jun 09, 2021
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Contract
Adverum is looking for a Pilot Process Development Associate, Downstream (contract) to join our team in Redwood City. This position reports into Technology Development Engineer II.  This individual will be a key member of the Pilot Process Development Team, focusing on Downstream activities.
 
This is a 6mo contract with an opportunity for extension.  
 
What you'll do:
  • Follow good documentation practices to maintain accurate records through a highly organized lab notebook and/or in a Batch Record.
  • Work closely with team members to perform buffer preparation.
  • Set-up, operate and maintain required downstream laboratory equipment.[JL1] 
  • Maintain reagent and sample inventories; order and organize supplies.
  • Assist with data entry and data analysis in Excel and/or other statistical programs.
  • May contribute to develop process models utilized in scale-up processes.  
  • Ensure safe workplace in compliance with the company and EHS' rules and regulations.
  • Work to evaluate process changes with the goal of optimizing the existing AAV downstream purification process to enhance robustness, scale-ability, and/or yield.
  • Work to identify optimize, revise, and update current process batch records, protocols, and procedures to make them more robust and streamlined.
  • Other responsibilities may be assigned as needed.

About you:
  • Requires a Bachelor’s degree (or higher) in chemical/biochemical engineering or related fields with 0 - 2 years of relevant experience.
  • Proficient in general and non-routine laboratory skills including aseptic technique, multi-channel pipetting and biosafety cabinet operations.
  • Conceptual knowledge of TFF (Hollow Fiber/Cassettes) UF/DF and Column Chromatography Purification.
  • Requires some knowledge of GxP standards, and the ability to apply compliance principles to Adverum’s laboratory practices.
  • Able to work in a fast-paced environment as a team player with effective communication skills.
  • Excellent computer skills; especially proficient in Excel and Word.
  • Strong desire to learn new technologies, skill sets, and the science behind AAV processing.
  • Strong teamwork and communication skills.

About Us
Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.

At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self.  We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation