Exec Director, Drug Metabolism

Location
Foster City, CA, United States
Posted
Jun 08, 2021
Ref
2150133
Required Education
Bachelors Degree
Position Type
Full time
Exec Director, Drug Metabolism
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

Gilead Sciences is a biopharmaceutical company that discovers, develops, and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide. Headquartered in Foster City, California, Gilead has operations in North America, Europe, and Australia. We are committed to transforming the promise of science and technology into therapies that can make a meaningful difference in patients' lives. We are passionate about advancing treatments for - and potentially curing - some of the world's most challenging and complex illnesses and bringing these scientific innovations to people in need. Focus on areas of high unmet needs, including HIV, HBV, HCV, Oncology, Inflammatory & Infectious diseases.

Executive Director, Drug Metabolism

Specific Responsibilities and skills for Position:

We are seeking an experienced, creative, and highly motivated DMPK expert with industry research experience focused on lead optimization, IND preparation, and nonclinical drug development for a wide variety of modalities including small molecules and complex biologics. In addition to overseeing a group of professionals, this position will be responsible for leading DMPK interactions with medicinal chemists, biologists, and toxicologists to facilitate the successful achievement of lead optimization and efficient progression of drug candidates in nonclinical development.

Essential Duties and Job Functions:

- Supervise and mentor a group of DMPK scientists supporting multiple drug discovery programs.

- Provide scientific guidance on lead optimization programs and work in close collaboration with discovery teams to optimize the DMPK properties of candidate drugs, including biologics.

- Provide non-clinical support for drug candidates in development programs.

- Develop and maintain close interactions with research and development groups

- Effectively communicate science and strategy across Gilead R&D.

- Identify and support external collaborations and evaluate business development opportunities.

Knowledge, Experience, and Skills:

The candidate should have a Ph.D. in chemistry, biochemistry, or a related discipline and a minimum of 15 years of pharmaceutical industry experience in DMPK. The candidate should have exceptional knowledge and skill in ADME and pharmacokinetics/pharmacodynamics as demonstrated through a strong publication record indicative of an in-depth understanding of the experimental methodologies and approaches, including in vitro and in vivo, utilized in lead optimization.

The candidate should have exceptional knowledge of metabolic routes of biotransformation, metabolite identification, and drug-drug interactions involving drug-metabolizing enzymes and transporters. The candidate must be able to work with multiple disciplines in drug discovery and provide exceptional guidance and innovative approaches to lead optimization teams in the discovery of novel drug candidates. The candidate should have extensive knowledge in nonclinical drug development and toxicokinetics, as well as the preparation of regulatory documents, e.g. INDs and NDAs. The candidate should also have extensive experience in the extrapolation of human pharmacokinetic parameters from nonclinical data and strong working knowledge in PK/PD modeling in order to interact effectively with clinical development programs. In addition, she/he should be a goal-oriented and effective leader. Additional requirements include effective mentoring of scientific staff and highly effective managerial, organizational, and communication skills.

For jobs in the United States:
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'EEO is the Law' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.
For Current Gilead Employees and Contractors:
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