Senior Scientist, Gene Therapy - Immunology Research

Location
Cambridge
Posted
Jun 08, 2021
Ref
5047144002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cells as engineered medicines. We are looking for enthusiastic scientists to advance our novel targeted gene therapy platform. The candidate is a highly motivated and creative scientist, and will thrive in a vibrant research environment with cross-functional teams.

This position will report directly to the program research leader within the department of Gene Therapy. The Senior Scientist will 1) lead the design, execution and planning of in vitro and in vivo studies to characterize gene therapy candidates using primary T cells and immune cells, and 2) define and deploy immunology work to help build and optimize our platform further. This position will require close communication and collaboration within and outside the Gene Therapy function.

DUTIES AND RESPONSIBILITIES
  • Integrate immunology background and provide scientific and strategic input to advance our platform
  • Design and execute in vitro or ex vivo assays for candidate characterization and selection using primary T cells, PBMCs, innate immune cells; develop new assay as necessary
  • Design and execute preclinical in vivo studies in mouse models, including dosing and immune cell analysis
  • Tissue collection and processing for downstream assays such as flow cytometry, cytokine release and molecular analysis
  • Bench work, troubleshooting, data recording, analysis, interpretation, and reporting
  • Presentation of data and progress to research leadership and teams
  • Manage junior scientists

QUALIFICATIONS
  • Doctoral degree (PhD 5+ years/Post-doc 2+ years) or MS (7+ years) in a relevant discipline (immunology, cell biology) with industry experience preferred but not required
  • Strong background in immunology, T cell biology
  • Hands-on experience with primary T cells, PBMC; or other primary immune cells is a plus
  • Expertise in multi-parameter flow cytometry, T cell phenotyping, T cell functional assays including cytotoxicity, proliferation, cytokine production.
  • Experience with lentiviral transduction of T cells is preferred
  • Experience with preclinical xenograft animal models and adoptive cell therapy is preferred
  • Proficiency in standard molecular and cell biology techniques (RNA isolation, qPCR, cell culture, ELISA/MSD)
  • Ability to work independently and in a team-oriented, highly collaborative environment
  • Highly organized with strong communication and analytical skills, and ability to multi-task.
  • Demonstrated experience with relevant software: Microsoft Word, Excel, PowerPoint, Graphpad Prism, FlowJo
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.