Senior Research Associate, Bioanalytical Assay Development

Cambridge, MA, United States
Jun 07, 2021
Required Education
Bachelors Degree
Position Type
Full time
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:

Intellia is seeking a highly skilled and motivated bioanalytical Senior Research Associate to join our growing team in Early Development & Translational Medicine. Your primary responsibilities will be to execute PCR-based methodologies to investigate, monitor, and quantify oligonucleotides to further the development of in vivo and ex vivo gene editing CRISPR/Cas9-based therapeutics. You will be responsible for quantification of sgRNA, Cas9 mRNA, AAV vector genes, and transgenes in biological matrices in non-clinical and clinical stages of development.

In this role, you will have an opportunity to collaborate cross-functionally to perform data analysis, review, and communicate findings to both internal and external partners. Other key responsibilities include:
  • Conduct experiments independently and in collaboration with colleagues
  • Select appropriate assay platforms that serves intended use
  • Evaluate novel methods
  • Execute various in-house bioanalytical PCR-based assays such as qPCR, qRT-PCR, ddPCR, and b
  • Analyze data for PK, PD, and distribution studies and contribute to data driven decisions and strategies to understand drug efficacy, safety, and mechanism of action
  • Compile assay qualifications, author bioanalytical reports, and communicate timelines and results to internal teams
  • Conduct assay failure investigations for both internal and CRO sample analysis functions
  • Contribute to regulatory documents (such as CTA and IND) to advance drug development

About You:
  • Graduating with a Master's degree in Biology, Chemistry, Biochemistry, or a related field OR Bachelor's degree in Biology, Chemistry, Biochemistry, or a related field with at least 2 years of industry experience
  • Laboratory skills, including summer research and/or internship experience
  • Experience in isolation, detection, and quantitation of RNA and DNA
  • Experience in troubleshooting new bioanalytical assays
  • The ability to work with blood and tissue-borne biological samples
  • Ability to independently run bioanalytical assays and to communicate effectively within team environment.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.