Scientist / Senior Scientist, Immunology / Cell Biology

COMPANY DESCRIPTION

Prometheus Biosciences is a San Diego-based public biotechnology company pioneering a precision medicine approach to the discovery, development, and commercialization of novel therapeutics and companion diagnostic products for the treatment of inflammatory bowel disease (IBD). The company's precision medicine platform combines proprietary bioinformatics discovery methods with one of the world's largest gastrointestinal multiomics database to identify novel therapeutic targets and companion diagnostic approaches that will enable tailored treatments based on molecular patient stratification.

SUMMARY

We seek a motivated, detail-oriented Sr. Scientist with strong background in immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

ESSENTIAL DUTIES & RESPONSIBILITIES

• Lead or co-lead drug-discovery programs from target hypothesis through IND-enabling studies
• Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development
• Analyze, critically interpret data and share results to project teams as required
• Keep meticulous records of experiments performed and maintain ELN entries
• Act as a resource for other scientists in the group

QUALIFICATIONS

• Sr. Scientist: PhD and typically 6 years of experience including post doc or 10 years of experience (MS)
• Scientist: PhD and typically 0-2 years including post doc OR 6 years of experience in industry (MS) or 8 years of experience (BS)
• Independent thinker that can generate scientific questions and design experiments to address them
• Hands-on lab experience in an industry drug discovery / development setting is preferred
• Strong cell culture skills and assay development experience are essential
• Experience developing ex vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets (T cells, B, cells NK cells, etc) is required
• Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues is preferred
• Experience using MSD, Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required
• Experience developing various cell-based assays, including luciferase reporter assays is required
• Working knowledge of animal models of IBD / auto-immunity is a plus
• Proficiency in data analysis using Excel and GraphPad Prism is required
• Experience with tissue explants and organoid systems is d
• Self-motivated with excellent problem-solving, organizational and communication skills

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.