South San Francisco, CA
Jun 05, 2021
BRIS 2.107
Biotech Bay
Required Education
Associate Degree
Position Type
Full time

We are seeking to hire a Senior Scientist/Principal Scientist/Associate Director with a track record in drug discovery, including the characterization of disease-relevant pathways and pharmacological activity of novel molecules in preclinical disease models. This position within the in vivo pharmacology group will afford the successful individual an opportunity to discover and develop innovative drugs to modulate an emerging and exciting biological concept in diseases of aging and to translate our science into a pipeline of differentiated medicines. The ideal candidate should be highly innovative and creative with relevant industry experience ranging from early discovery, target identification, lead optimization, translational pharmacology, to IND submission. Experience/expertise in the ophthalmology research field is a plus.

The successful candidate will be a strong individual contributor and team leader with experience managing and developing research associates and scientists.  Responsibilities will include overseeing the in vivo strategy including the selection/development/validation of in vivo models that focus on understanding the pharmacodynamic activity and translation to disease-relevant efficacy. The duties of the job include experimental design and execution, analysis and interpretation of data, regular presentations (verbal/written) of results and interpretation at group, project team, and Discovery team meetings. Depending on management experience the candidate could be responsible for overseeing activity and mentoring junior staff in the in vivo pharmacology department. Title/compensation will be based on experience.

  • Ph.D. with 5-8 years of scientific experience or Bachelor’s/Master’s degree with >10 years in post-graduate work (at least 3 years industry experience). Degree in Pharmacology, Physiology, Cancer Biology, Developmental Biology or a related field is essential.
  • In-depth expertise with validation and execution of in vivo disease models with a preference for experience with in vivo models of ocular disease.
  • Evidence of independent scientific ability (g.,post-doctoral training) and a track record of scientific accomplishments through publications, patents, and invited presentations.
  • Experience with quantitative PCR and protein-based methods in tissue samples as well as immunohistochemistry.
  • Ability to manage complexity and ambiguity in a highly matrixed work environment.
  • Track record of managing, developing, and mentoring junior scientists and research associates.
  • Creativity and the ability to lead and/or work within an interdisciplinary team in order to achieve technical and corporate milestones.
  • Robust experimental design and troubleshooting skills, and excellent data analysis/mining/statistics capabilities.
  • Experience leading and mentoring teams of junior research staff and supporting personal and professional development of team members.
  • Experience writing IND reports to support regulatory filings preferred.