Translational Research Scientist

Employer
Q32 Bio
Location
Cambridge, MA, United States
Posted
Jun 04, 2021
Ref
932846371
Hotbed
NextGen Bio
Required Education
Bachelors Degree
Position Type
Full time
Q32 Bio is advancing an innovative platform and integrated portfolio of immunomodulatory therapies. With our strategy of protein-based molecules we aim to deliver life-changing treatments for patients with a variety of diseases for whom inadequate options exist.

Our dynamic, industry-experienced team is growing. We are seeking a creative and highly motivated translational scientist with a strong background in immunology/inflammation who desires to be part of an energetic, fast-paced and collaborative team. This is a hands-on lab position in a highly dynamic, team-oriented environment. Qualified candidates should be independent, hard-working, highly motivated, and possess a proactive attitude and strong desire to discover novel biology and potential new therapeutics. Candidates should also fit in well with the collaborative, rigorous and entrepreneurial spirit of our company culture.

The translational science scientist will carry out research that will support the clinical development of ADX-097, a tissue targeted complement regulator protein and ADX-914, an anti-IL-7R antibody. This will include developing approaches to support establishing proof of mechanism (POM) evaluation in the clinic, relevance of target biology to human disease, and biomarker development. This candidate will also work closely with cross-functional project teams to discover and implement novel pharmacodynamic and predictive biomarkers and prioritize disease indications for both the ADX-097 and ADX-914 programs. The role will require partnerships with scientists and clinicians in the company and with outside collaborators and CROs to develop capabilities that have the potential to directly impact clinical trial strategy and design, including patient stratification. These efforts will be integrated into the larger clinical development plans for our lead programs. Ideally, the candidate would have extensive experience and scientific knowledge in dermatology indications.

RESPONSIBILITIES:
  • Collaborate with internal teams of research scientists to support preclinical research efforts that advance and inform early stage development programs
  • Partner with the clinical development and operations groups to integrate the discovery and validation of biomarkers into clinical trial design, and to correlate biological response with clinical response/outcome enabling personalized cancer medicine
  • Work with clinical development colleagues to facilitate translational biomarker efforts for clinical stage programs including assay development and management of CRO vendor relationships
  • Actively engage with clinical and research cross-functional teams to prioritize and select disease indications for Q32 Bio programs
  • Establish external collaborations with key KOLs to support our human disease translational strategy. This will include including designing studies and gaining access to human disease samples and datasets, guiding the analysis and interpretation of results, and integrating the findings into clinical development plans
  • Coordinate and organize the collection and analysis of tissue samples internally and with external partners
  • Oversee the discovery and development of pharmacodynamic and predictive biomarkers for clinical development candidates
  • Use extensive knowledge of inflammatory and autoimmune disease biology, and genetics to develop biomarker hypotheses
  • Work with CROs to carry out validation and clinical application of biomarker assays.
  • Initiate and maintain academic and industrial collaborations
  • Generate data and written packages for human disease translational activities to support regulatory submissions.

REQUIREMENTS/QUALIFICATIONS:
  • PhD or MD/PhD with a well-documented background of scientific achievement, and a minimum of 5 years related laboratory experience in biotech/pharma or an academic environment
  • Track record of publications
  • A demonstrated record of cutting-edge research in translational immunology and inflammatory diseases and industry experience is desirable
  • Effective communicator and excellent organizational skills


Please apply via email to info@q32bio.com .