Protein Biochemist

Location
Pasadena, CA, United States
Posted
Jun 04, 2021
Ref
4205404003
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Company Overview: Terray Therapeutics is a venture-backed biotechnology company leveraging our vast high-quality data to optimize the path from discovery to transformative therapeutics. Our approach delivers on the promise of computation to revolutionize drug discovery. Through our closed-loop wet lab discovery platform and data-rich AI, we overcome existing constraints on chemical data by systematically mapping the biochemical interactions of massive and diverse small molecule libraries to identify novel therapeutic compounds. Access to this quantitative data at scale allows us to intelligently navigate an infinitely extensible and highly diverse chemical space to efficiently design, discover and optimize small molecule therapeutics. Our internal development programs are focused on immunology. In addition to these programs we also work with leading pharmaceutical companies.

Our integrated computational platform, tNova, harnesses our novel affinity binding technology, tArray, unique resynthesis capabilities, and broad biology infrastructure. tArray is the foundation of our discovery engine. It enables us to screen hundreds of millions of compounds in minutes and return quantitative data on each compound. Vast, high purity, and high diversity compound libraries are rapidly iterated using best-in-class chemistry to unlock chemical insights at the scale necessary to power AI-driven drug discovery.

Position Summary: Terray Therapeutics is seeking a highly motivated, creative, and experienced protein biochemist. As an integral member of our biology group, the candidate will lead the design, expression, purification, labelling and analytical characterization of protein targets for use in our affinity screens. The quality and purity of the proteins is critical to the data output from our screens. The position will report to the Head of Biology.

The core responsibilities of this job will be:
1. Identify and design appropriate protein constructs for targets of interest for screening on Terray's small molecule arrays
2. Manage protein expression and purification efforts at external CROs for a broad range of protein targets
3. Perform analytical characterization and labelling of protein preparations
4. Establish protein expression and purification capabilities at Terray as needed
5. Develop and execute high through-put affinity, biochemical or activity assays to evaluate hits from affinity screens
6. Work closely with scientists across the company and communicate results at project team meetings

Experience and Qualifications: Given the company's size, anticipated growth and fast-paced environment, the organization requires a Scientist who is thoughtful, high energy and can partner with the broader organization to further enhance our next generation drug discovery capabilities.

Part of Terray Therapeutics' success is nurtured by a hands-on work environment where everyone is accountable, everyone is vested in a vision of excellence, and everyone actively takes part in the success of the business. Terray Therapeutics supports a positive work environment comprised of engaged employees who feel appreciated, recognized and free to be creative.

Qualifications include:
  • PhD in the field of protein biochemistry, enzymology and/or structural biology
  • 5+ years of hands-on experience in protein synthesis, purification and modification
  • Broad experience in expressing recombinant proteins in a variety of expression systems and modern molecular cloning techniques
  • Extensive hands-on experience in protein purification using a variety of chromatographic techniques required
  • Hands-on experience in use of analytical/biophysical techniques (HPLC, DLS, DSF, etc.) for assessing stability, solubility, and oligomerization status of proteins required
  • Experience with binding affinity measurements (SPR) highly desired
  • Experience in structural biology (X-ray crystallography, NMR, Cryo-EM) highly desired
  • Experience with enzymology, protein-protein interaction and/or DNA/RNA-binding proteins would be a plus
  • Excellent organizational, interpersonal and communication skills and can thrive in a highly collaborative research environment
  • Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data

She/he will exhibit the ability to work well under pressure to provide results in a short timeframe. The company is looking for a highly responsive, goal-oriented individual who will bring significant energy and drive to solve complex technical problems and help us achieve our mission to advance human health.