Scientist, New Modalities
- Employer
- Mammoth Biosciences
- Location
- Brisbane, CA, United States
- Start date
- Jun 4, 2021
View more
- Discipline
- Science/R&D, Biotechnology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
OPPORTUNITY
Mammoth is seeking a Scientist with expertise in building genome editing tools in mammalian contexts to join our growing genome editing technology team. The ideal candidate will have direct experience with developing novel CRISPR-based genome manipulation technologies including, but not limited to, gene editing, gene regulation, epigenetic modulation, and base editing. A strong background in mammalian cell engineering and synthetic biology is essential. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals.
KEY RESPONSIBILITIES
- Screen CRISPR Cas systems to test their potential use in complex genome manipulation tools
- Construct and validate various CRISPR based genome manipulation tools in mammalian cells
- Design CRISPR-based genome manipulation tools with novel modalities
- Build assays to evaluate diverse genome manipulation outcomes including on-target and off-target effects
- Keep up with relevant literature on the latest developments in the field
- Communicate key scientific data to project teams and senior management with a clear interpretation of data and proposal of next steps
- Collaborate with others on the team and, when applicable, manage direct reports
REQUIRED QUALIFICATIONS
- Ph.D. in molecular and cell biology, bioengineering, biochemistry, or a related field
- 3+ years of experience in (an) academic and/or industry setting(s)
- Hands-on experience of CRISPR based gene editing machinery development and assessment in mammalian cells
- Experience using one or more gene editing tools (e.g gene regulation, epigenetic modulation and/or base editing) with an understanding of their optimization in mammalian cells
- Demonstrated experience with mammalian cell culture of different mammalian cell types, both primary and immortalized cells
- Experience with DNA/RNA isolation, molecular cloning, and PCR/qPCR/next-generation sequencing experiment design and execution
- Proficiency in cell biology skills such as flow cytometry and FACS
PREFERRED QUALIFICATIONS
- Experience with mRNA and protein production of gene-editing components
- Familiarity with various mammalian cell delivery strategies and their optimization process, including lipid-based transfection, electroporation, viral vector, etc.
- Experience with luminescence/fluorescence cellular assays
- Proficient in R/Matlab/Python or other programming languages and familiarity with their usage in bioinformatics data analysis.
- Experience with protein engineering to improve gene editing tools
BENEFITS
- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness, caregiver and ergonomics benefits
- 401(k) with company matching
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Company
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
- Website
- http://www.mammoth.bio/
- Phone
- (650) 294-8583
- Location
-
South San Francisco
CA
94080
United States
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