Senior Research Associate - Molecular Assay Sciences

Location
Cambridge
Posted
Jun 04, 2021
Ref
5044428002
Discipline
Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is involved in developing gene and cell therapeutics for the treatment of a broad range of diseases and conditions. Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cells as engineered medicines, have the vision to do creative things, and the determination to execute that vision. As a member of the Development Sciences, Bioanalytical Sciences group, you will work within a highly dynamic and cross-functional environment on projects of diverse scope and across multiple therapeutic areas. To accelerate the development of transformative medicines, we seek a Senior Research Associate to build essential platform capabilities as well as develop and implement functional assays to support bioanalytic genomic and transcriptomic assays, IND enabling studies and work with CROs. The Senior Research Associate will perform in genomic and transcriptomic analysis of lead gene and cell therapy candidates in complex pharmacological and clinically relevant models. He/She will have experience in ddPCR, RT-PCR, NGS and other related analytical platforms. The successful candidate will have demonstrated technical proficiency, exhibit scientific rigor and independent thought as well as the ability to thrive in a team-oriented environment.

DUTIES AND RESPONSIBILITIES
  • Uses professional concepts in accordance with company objectives to solve problems in creative and effective ways.
  • Develop and perform DNA/RNA isolation from different cell types and organs for in vivo studies.
  • Work with various types of immune cells
  • Establish and qualify RT-PCR and ddPCR assays for different candidate targets
  • Establish and qualify NGS methods that support IND enabling studies
  • Work with CROs on development and qualification of molecular biology methods
  • Independently plan, coordinate and execute experiments
  • Independently and under the supervision of Senior Scientist and other colleagues work to analyze and interpret experimental results
  • Makes detailed observations, document experimental methods in a well-maintained laboratory notebook
  • Present results at team meetings
  • Facilitate discussion with other team members as necessary to ensure the completion of the team's projects
  • Comply with standard laboratory practices and company policies.

QUALIFICATIONS

Basic Qualifications
  • Master's degree or Bachelor's degree with 3-5+ years of laboratory experience in an academic or industry setting and proven proficiency performing independent research.
  • Proven extensive hands-on experience in PCR, cloning, RT-PCR, qPCR.
  • Experience in culturing mammalian cell lines with demonstrated competence in sterile cell culture technique and standard laboratory procedures.
  • Experience working with in vivo and in vitro models of disease.
  • Ability to proactively engage groups with diverse functions within a highly matrixed organization.
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on cross-functional teams.
  • Technical proficiency, scientific creativity, independent thought and ability to actively communicate with scientists throughout the organization.
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications
  • Industry experience, preferentially in BioA environment
  • Experience with ddPCR
  • Experience with NGS platforms
  • Experience with high-throughput and automatic platforms is a plus
  • Experience with general molecular biology methods (Western, Northern, PCR, cloning, in situ RNA hybridization, cell culture)
  • Ability to communicate and lead change.
  • Ability to work in a fast-paced, dynamic environment.


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.