Process Development Scientist - Pre-Pivotal DP Synthetic Enabling Technology
HOW MIGHT YOU DEFY IMAGINATION?
Youve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge youve worked hard to acquire and the passion you already have. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.
Process Development Scientist - Pre-Pivotal DP Synthetic Enabling TechnologyLive
What you will do
Lets do this. Lets change the world. In this vital role you will serves as a key Drug Product Technology partner to Process Development and Research & Discovery.
You will play a meaningful role in the solidstate form evaluation and characterization and the application of innovative materials science approaches to guide the DS and DP development.
Solid state form selection and characterization support for DS and DP process development for small molecules and biologics portfolios from Discovery to Life Cycle Management.
Generation of fundamental knowledge to establish form development strategies and Target Product Profile.
Conduct physicochemical property evaluations utilizing in silico models to guide development path.
To craft and conduct screening and crystallization experiments of small molecule drug candidates (including salts, cocrystals, hydrates, solvates and polymorphs).
To evaluate and recommend suitable solid state drug substance forms, identify any gaps associated with process development and provide mitigation strategies to the development teams.
To perform a range of solid state characterization of pharmaceutical materials, including particle characterization, Xray diffraction, thermal analysis and spectroscopy.
To assess structureproperty relationship of DS forms and provide material options with the desired physicochemical properties for DS/DP development.
To support departmental activities including training staff and present scientific results at internal/external meetings.
To contribute to regulatory and intellectual property filings.
To keep track of new technologies and collaborate with internal and external organizations.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The scientist professional we seek is a self-starter with these qualifications.
Doctorate or Doctorate degree completed by December 2020
Masters degree and 4 years of industry experience
Bachelors degree and 6 years of industry experiencePreferred Qualifications:
Doctorate Degree in one of the following areas: Chemistry, Chemical Engineering, Materials Science, Pharmaceutical Science or a related scientific subject area with 24 years of postdoctoral or industry experience.
Handson experience and expertise in crafting and executing form screening and crystallization experiments to assess polymorphism, salt/cocrystal formation and solvate/hydrate formation.
Indepth experience in solidstate techniques (DSC, TGA, XRD, microscopy, DVS, particle characterization, Raman, IR, etc.)
Good understanding in computational crystallography and data science to predict the properties and performance of drug substances and drug products.
Solid understanding in preformulation and biopharmaceutics concepts to evaluate the developability of small molecule drug candidates.
A successful track record of peerreviewed journal publications and presentations.
Some of the vast rewards of working here
As we work to develop treatments that take care of others, so we work to care for our teammates professional and personal growth and well-being.
Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.comEqual Opportunity Statement
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.
Join UsIf you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.