Research Associate, Pre-Clinical

South San Francisco, California, United States
Jun 03, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the "intelligence" of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.

At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

We are seeking a highly motivated candidate with the following skills to join our Pre-Clinical In Vivo team and contribute to early-stage oncology projects. A successful applicant will be comfortable performing high risk/high impact research, work collaboratively across various projects to meet milestones, and play a key role in building the culture of the company as it grows. Applicants should have current knowledge of pre-clinical tumor models and animal handling and dosing.

    • Perform in vivo studies to evaluate efficacy in rodent models
    • Proficient in the administration of test substances by various basic methods (i.e., IP, IV, SC, topical, etc.)
    • Proficient in rodent bleeding (cardiac puncture, submandibular, tail vein, etc.), necropsy and tissue harvest procedures
    • Perform in vivo imaging to monitor tumor growth
    • Manage and observe animals for general health and overall wellbeing
    • Adhering to SOPs to ensure study integrity and quality
    • Collaborate with research teams on relevant ex vivo assays (Flow cytometry, PCR, ELISA, IHC, etc.)
    • Maintain accurate experiment records in various internal databases and perform basic data analysis
    • Perform other duties as directed by Management
    • Train research staff as needed

    • Bachelor's degree in life science or related discipline
    • 2+ years of experience in animal laboratory setting
    • Strong hands-on experience with animal handing, dosing (IP, IV and SC), bleeding, necropsy and tissue harvest
    • Experience with cell culture is a plus
    • The ability to independently perform all methods and conduct all study types commonly employed by the team
    • Good organizational and documentation skills
    • Dedication to working in a team-oriented environment to contribute to shared project
    • Strong work ethic, self-motivation, and ability to multi-task in a fast-paced work environment
    • Excellent communication skills with ability to effectively communicate with other research teams

Salary and Benefits
    • Base pay and stock options to be determined based on application qualifications with the aim of being competitive with similar roles in the area
    • Significant growth opportunity as the company expands

Senti Bio is a leading gene circuit company designing gene circuits to create a new generation of "smarter medicines" and enhance the therapeutic effectiveness of cell and gene therapies against a broad range of diseases that are unaddressed by current standards of care. We are proud to count Leaps by Bayer, NEA, 8VC, Matrix Partners China, Mirae Asset Capital, Amgen Ventures, Intel Capital, Ridgeback Capital, Lux Capital, KB Investment, Pear VC, Smilegate Investment, Menlo Ventures, LifeSci Venture Partners, Alexandria Venture Investments, Allen & Company, LifeForce Capital, Omega Funds, Nest.Bio, Gaingels, Noveus Capital, and Goodman Capital among our investors. Senti Bio is based in South San Francisco, CA, USA.