Research Associate, Neuroscience (In vivo)

Location
Tarrytown, New York, United States of America
Posted
Jun 03, 2021
Ref
25146BR
Required Education
Bachelors Degree
Position Type
Full time
We are seeking an associate to join our dynamic neuroscience research group. This person will perform hands-on research studies designed to investigate novel targets and mechanisms in neurodegenerative disorders. The primary focus of this will be Friedrich's ataxia and motor neuron disease.

As a Research Associate on the Neuroscience team, a typical day might include the following:
• Designing and performing experiments to characterize in vitro and in vivo models of Friedreich's Ataxia and screen potential therapeutic approaches in these models.
• Conducting experiments in mice and rats, including handling, performing behavioral analysis, injecting compounds by a variety of routes, and dissecting tissues for histochemical and biochemical analysis.
• Using a variety of cell lines including mouse ES cells, iPSC-derived neurons, and mouse primary neuronal cultures to screen therapeutics.
• Isolating RNA from cells and mouse tissue and perform Real-time qPCR for quantification of gene changes from disease and therapeutic intervention.
• Utilizing immunohistochemistry, biochemistry, and ELISA to profile in vitro and in vivo models of motor neuron disease and screen novel therapeutic compounds.
• Performing data analysis on experimental data as well as troubleshooting under minimal direction.
• Staying current on relevant literature in order to further develop scientific expertise, new assays and expand scientific/technical knowledge and skill sets.
• Participating in group and departmental meetings and giving presentations.
• Contributing to writing of protocols and articles for publication.

This role might be for you if:
• You have strong communication and presentation skills.
• You have the ability to work both independently and collaboratively.
• You can proactively work on multiple projects and prioritize as needed.

To be considered for this opportunity, you must have a Bachelor's degree with three years of experience or Master's Degree with one year of experience in neuroscience, biochemistry, molecular biology, biology, or a related discipline. Experience with mammalian cell cultures, primary neuronal cultures, immunocytochemistry, immunohistochemistry, SDS-PAGE and western blotting strongly preferred. You should be comfortable working with mice and/or rats. A solid understanding of experimental design, statistical analysis, and data presentation are also required. Experience with in vitro and/or ex vivo examination of mitochondrial and/or lysosomal activity is a plus. Hands-on experience with iPSCs and/or mouse ES cells is highly desirable. Experience with RT-qPCR and basic cloning skills a plus. Experience with fluorescent microscopy including confocal microscopy, and image analysis using Image J, Halo, or related software is desirable.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
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