Senior Scientist, iPSC T Cell Therapeutics

JOB PURPOSE

Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of engineered cells as medicines. We are looking for enthusiastic scientists to advance our novel hypoimmune (HIP) T cell therapy platform. The candidate is a highly motivated and creative scientist and will thrive in a vibrant research environment with cross-functional teams.

This position will report directly to the program research leader within the department of T cell Therapeutics. The Senior Scientist will lead the design, execution, and planning of in vitro and in vivo studies to characterize iPSC-derived T cell differentiation and function. This candidate should have a deep understanding of the developmental biology of hemopoietic lineages from stem cells, especially T and B cell development. This position will require close communication and collaboration within T cell Therapeutics and with the HIP program team.

DUTIES AND RESPONSIBILITIES

• Simultaneous culture of iPSCs with different gene modifications, their characterization and purification
• Establish iPSC-based T cell differentiation protocols to support the discovery and characterization of therapeutic programs
• iPSC clonal selection, culture and functional characterization (in vitro and in vivo)
• Work and provide subject matter expertise with a cross-disciplinary team to optimize cell culture approaches
• Strong communication with respect to scientifically rigorous findings via verbal and written communications, visualizations, and presentations
• Inspire his/her teammates from the bench
• Liaise to development function and executive leadership regarding project timelines and deliverables
• Understands and applies relevant scientific literature to the design of experimental protocols.
• Actively contribute to the strategic direction of the department and company objectives in creative and effective ways
• Demonstrate Sana's core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen
• Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
• Innate ability to assess talent that will help grow the organization and add Sana's culture
• Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
• Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment

QUALIFICATIONS

Basic Qualifications

• PH.D. in biological science or equivalent and a minimum of 5+ years of stem cell and T cell biology related experience
• Strong background in immunology and T cell development
• Direct experience in in vitro and in vivo cell differentiation systems and stem cell culture
• Experience in iPSC-relevant experimental techniques, including both in vitro cellular assays and in vivo transplant models
• Strong scientific background and publication record with proven high levels of performance
• Excellent written communication skills and the ability to present effectively to teams with diverse scientific backgrounds
• Ability to adapt to increasing scope and complexity of work
• Comfortable in a fast-paced research environment with minimal direction, and able to adjust workload based upon changing priorities
• Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications

• Experience in differentiating hematopoietic stem cells from iPSC
• Experience in immunobiology assays to study adaptive and innate immune responses in vitro and in vivo
• Expertise in advanced genomic platforms for cell characterization
• Experience with gene editing technologies

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.