Principal Scientist, Immunology

Philadelphia, PA
Jun 02, 2021
Pharm Country
Required Education
Position Type
Full time

Position Title: Principal Scientist, Immunology

Position Level: V.P., Immunology

Reports to: Mark Wallet


Company Background:

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century’s genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care. 


Century’s foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.



The candidate would report to the VP, Head of Immunology. They would direct research activities to understand cutting edge new iPSC-derived cell therapies for cancer. The ideal candidate would bring expertise in T cell and NK cell biology and help the immunology team prioritize research activities, identify novel opportunities for improving cell therapies, develop and refine assays, deploy new technologies, and deeply characterize Century’s iPSC-derived T and NK cells.



  • Manage a growing team of scientists who are studying the immune properties of iPSC-derived T and NK cells
  • Coordinate with other team leads across sites to efficiently prioritize responsibilities and work collaboratively on key challenges (Philadelphia, Seattle, and Hamilton, ON)
  • Manage data reporting and presentations from the team
  • Help team design studies that characterize iPSC-derived T and NK cells using molecular biology, biochemistry, cell biology, and omics platforms
  • Work cross-functionally with iPSC biology (NK and T cell differentiations), genome engineering, and protein engineering to manage workflows and prioritize activities
  • Deliver regular presentations to senior leadership



  • PhD in relevant field (immunology, molecular biology, cancer biology, etc.) and 8+ years of relevant postdoctoral experience, or MS in relevant field and 15+ years of relevant professional experience



  • Technical expertise in core methodologies regularly used to study the human immune system (flow cytometry, microscopy, cell culture, immune assays, etc).
  • Evidence of productive research in T or NK cell biology with a track record of publications
  • Independently uses expertise to design and implement critical experiments, tools and technologies
  • Biotech or pharma experience leading direct reports
  • Excellent communication skills – works collaboratively and builds consensus
  • Ability to multitask and maintain an even keel demeanor under pressure
  • Reliably completes work and reports on time
  • Experience with IND-enabling studies and drug development is a plus but not required