Scientist I

92126, San Diego
Competitive salary
Jun 01, 2021
Required Education
Position Type
Full time

BioTheryX is a privately held, clinical-stage biotech that is committed to transforming the treatment of cancer and immune disorders through the development of novel therapies that modulate disease-causing proteins.

Our principal technology platform centers on targeted protein degradation with our PHM® ‘molecular glues’, which enable the design of small molecules to regulate protein equilibrium. Molecular glues can be used to either create a complex of proteins that is more stable by attaching them, giving them better functionality by gluing a diseased protein to a “regulator” protein. This technology utilizes the body’s own protein disposal system to selectively degrade and remove disease-causing proteins. We believe our technology has the potential to address a broad range of disease targets, including those that have to date been considered undruggable.


We are seeking a talented and highly motivated scientist to join a multidisciplinary team dedicated to the discovery of novel targeted protein degradation therapeutics. The scientist will support early drug discovery projects with a focus on developing experimental approaches to elucidate drug mechanisms of action, including target validation. The successful candidate must have in-depth knowledge of molecular and cellular oncology, immune-oncology, and related areas.


Education, Experience and Key Technical Skills:

  • Ph.D. with 1-3 years of post-doctoral or industry experience in biology or life sciences (cancer biology, immunology, pathology, molecular biology, cell biology) and related areas

  • Strong experience in a wide array of molecular and cell biology assays and in assay development and optimization, high-throughput cellular assays, western blots, immunoprecipitation, qPCR, ELISA, multicolor flow cytometry, Fluorescent microscopy,

  • Experience with target identification/validation using small molecule inhibitors, proteomics, and genetic manipulation (shRNA, CRISPR)

  • Establish stable/drug-resistant cell lines, viral vector design and transduction techniques (retroviral, lentiviral)


Responsibilities and Expectations:

  • Independently design, execute and analyze experiments with a variety of biochemical, cellular, genetic, and pharmacological techniques to advance multiple candidates from discovery research to clinical development 

  • Excellent oral and written communication skills, and the ability to present results at project team meetings and conferences

  • Excellent organizational and record-keeping skills


What BioTheryX Offers:

  • Competitive Salary

  • Paid Time Off (PTO) Plan

  • PPO Medical Plan

  • Dental and Vision Plans

  • Basic Life Insurance and AD & D Insurance at no cost to the employee

  • 401k Plan

  • Employee Assistance Program (EAP)


Equal Employment Opportunity

BioTheryX is an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.