Principal Scientist, Cancer Biology

Redwood City, California
Jun 01, 2021
Required Education
Associate Degree
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies.  Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

The Principal Scientist will join the Cancer Biology research team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol-Myers Squibb (BMS) in Redwood City, CA. This team is composed of cancer biologists/cancer geneticists who work closely with immunologists/immuno-oncologists and stroma biologists focused on developing therapeutic targets integrated across the tumor microenvironment.  Our mission is to provide transformative therapeutics to cancer patients that improve response rates and durability to this challenging disease.

The qualified candidate is a highly motivated, interactive, and creative individual who possesses substantial experience in studying tumor biology and genetics. The candidate should have been exposed to or have experience leading pre-clinical drug discovery programs in an industry setting.  The candidate will also be expected to contribute to the team’s project portfolio by developing new project hypotheses (gleaned from literature reports, evaluation of public and proprietary tumor profiling datasets, pre-clinical mechanistic models and functional screens, etc.), validating the hypothesis in pre-clinical models, developing translational hypothesis to guide their clinical application and develop assays to support early pre-clinical drug development. The successful candidate will manage 2-3 technical associates that provides a “lead in the laboratory” opportunity to mentor excellent science and technical development of these associates.  S/he will keep up-to-date in the literature related to his/her field, act as an expert resource in his/her scientific field and in related disciplines.

The ability to design and execute decision driving experimental and strategic plans to advance portfolio projects is required, as is a demonstrated proficiency in the use of informatics tools and translational profiling data. To be successful, the candidate must possess proficiency in verbal and written communication, capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. As we work in a highly matrixed environment, the candidate will also need to be influential and effective in sharing ideas and advice across the site (as well as across the company) to drive innovation to advance our portfolio and to work effectively with all relevant and necessary functions within BMS.


  • A Ph.D. degree with a minimum of 3-5 years of Industry experience in cancer biology and genetics or a closely related field is required.  

  • Experience/exposure to preclinical drug development in an industry setting, especially in small molecule drug discovery.

  • A proven track record in the field of cancer biology and genetics, as evidenced by publication record is required.

  • Excellent in vitro biology skills, experimental design, and execution is required, as is expertise to independently apply bioinformatics and data mining through multi-variate analysis.

  • Ability to effectively interact with core bioinformatics colleagues, as well as to use desktop tools/interfaces (e.g., Oncoland, Wuxi) and public databases (CBIO, Achilles, etc.) is required.

  • Experience in the design, validation, and execution of genetic and/or phenotypic screens is desired. 

  • Excellent interpersonal skills with the ability to interact effectively to influence people, internally and externally, is required.   

  • The ability to manage a small laboratory group is expected, including providing growth and development opportunities for associates reports. 

  • This position is located in Redwood City, CA. There will be less than 10% travel.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.