Senior Scientist, In Vivo Pharmacology
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
We seek an experienced, productive Scientist in the field of Immuno-Oncology/Oncology to join our In Vivo Pharmacology team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, California. You will play an essential role in the development of advanced models of cancer and the discovery of novel therapeutics for the treatment of cancer leveraging both cancer cell and immune intrinsic biology. You will be a senior member of the team and have a proven track-record in supporting drug discovery programs. Additionally, you will mentor and guide junior colleagues fostering a team environment.
You will actively participate in our pre-clinical drug discovery and development projects by implementing new cutting-edge in vivo models of cancer. A wide range of animal models including syngeneic, GEM, CDX, PDX and humanized tumor models are used. The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work in a multi-functional team environment. You will gain and provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from target identification/validation, to IND enabling activities and ultimately to clinical Proof of Concept in patients. You will characterize and develop small and large molecule therapeutics in close collaboration with your colleagues within in vivo pharmacology and partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams. Ideal candidates will have a strong background in characterizing the tumor microenvironment and possess excellent communication skills with a strong commitment to scientific objectivity and excellence.
Conduct high quality in vivo studies to evaluate targets, combination strategies, biomarkers and establish efficacy, PK/PD relationships.
Demonstrate independence in planning and executing complex in vivo studies.
Be impactful in a team environment. Demonstrate reliability and objectivity to produce high quality results with reproducible data that enables clear decision-making.
As a subject matter expert for in vivo models, you will mentor colleagues on best in vivo practices and guide teams on efficient work environment.
Compliance with IACUC and AALAC regulations.
Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates. Advanced in vivo cancer models include syngeneic, genetically engineered mouse (GEM) and humanized tumor models.
Interpretation, documentation and presentation of experiments within a multidisciplinary team environment. Work closely with project leads to ensure our drug discovery programs have all critical in vivo data to enable project stage dependent decisions
Qualifications and Requirements:
BS or MS in cancer biology, immunology or a related discipline and demonstrated expertise in the tumor microenvironment, oncogenic signaling pathways or immuno-oncology is required. This is a senior role within the in vivo pharmacology group and requires 10 years of relevant experience.
Excellent hands on in vivo skills (dosing, tissue/blood collection, survival surgery).
Proven skill with subcutaneous and orthotopic syngeneic tumor models (implantation, measurement and randomization).
Deep understanding of mouse oncology models - what they provide and their limits
Demonstrated curiosity - desire to continue learning and developing
Understanding of other aspects of cancer - stromal, immune, ontogeny, etc.
Industry and/or translational drug discovery experience required.
Expertise in setup and execution of complex studies (eg. small molecule PK/PD studies)
Effective interpersonal and communication skills to interact with internal and external colleagues fostering a collaborative workplace environment.
Ability to mentor and train junior colleagues.
Expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA, flow cytometry, scRNAseq, organoids is a plus.
Experience with IVIS, ultrasound imaging and/or focal irradiation is a plus.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to firstname.lastname@example.org. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.