Principal Scientist - Translational/Biomarker Development Immuno-Oncology

Redwood City, California
Jun 01, 2021
Required Education
Associate Degree
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Principal Scientist- Translational Research, Immunomodulatory Group

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies.  Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

The Principal Scientist will join the Immuno-oncology Translational Research team at Bristol-Myers Squibb in Redwood City, CA to lead efforts to execute on translational research plans, assist with biomarker strategies, and develop biomarker assays for immune targets in the tumor microenvironment.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses substantial experience in translational science and the biology of human immune cells, preferably of myeloid lineage, in the tumor microenvironment.  The candidate will lead a small group that will work closely with various target teams to build translational research and biomarker assay packages to support advancement of therapeutic candidates. The candidate will closely interact with discovery and biomarker groups to test hypotheses-driven and mechanism of action questions.

The successful candidate has superb verbal and written communication skills and is capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will act as an expert resource in his/her scientific field and in related disciplines, and collaborate across a highly matrixed organizational structure.

Responsibilities include, but are not limited to, the following:

  • Interface with discovery and biomarker leads to build translational research packages.

  • Execute on the translational research packages.

  • Interface with biomarker leads to guide and develop biomarker strategies for clinical studies.

  • Develop and execute assays to support biomarker strategies.

  • Identify and potentially develop new technologies and assays relevant for biomarker analysis.

  • Perform and manage in-house, collaborative or CRO-based research to support multiple projects.

  • Actively participate in internal and external scientific meetings through presentations and critical evaluation of both internal results and emerging scientific literature.

  • Act as an expert resource in his/ her/ their scientific field and train colleagues in established methodologies, troubleshooting and the development of novel techniques.

  • Responsible for documenting and reporting research findings

  • Oversee a group with 1-2 research associates


  • A Ph.D. degree with 5+ years of relevant experience in industry performing research and biomarker development for immuno-oncology targets, preferably against myeloid-lineage cells.

  • Experience with biomarker and assay development for early phase clinical trials.

Skills and experience:

  • Experience in multiple technologies/assays, including flow cytometry, immune functional assays, next generation sequencing, IHC, and bioinformatics.

  • Experience with biomarker strategy development and implementation.

  • Experience with assay development to execute on biomarker strategy.

  • Experience with primary human immune cells of human origin and the ability to utilize them to build mechanistic understanding of disease biology.

  • Ability to learn and advance cutting-edge technologies.

  • Strong analytical skills and problem-solving capabilities

  • A sophisticated understanding of immunology/immuno-oncology, as evidenced by publication record.

  • Comprehensive understanding of immunology as it applies to cancer.

  • Management/supervisory experience and passion for developing talent and building a highly collaborative and interactive team.

  • Excellent interpersonal skills with the ability to effectively interact, internally and externally. 

  • Ability to effectively present scientific data and concepts across various forums is required.

This position is located in Redwood City, CA and will be 10% lab-based. There will be less than 10% Travel.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.