Senior Associate Scientist, In Vivo Pharmacology Oncology (non-PhD)
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) focuses on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.
We seek a creative Associate Scientist in the field of Immune-Oncology/Oncology to join our In Vivo Pharmacology team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, California. The successful candidate will play an essential role in the development of advanced models of cancer and the discovery of novel therapeutics for the treatment of cancer leveraging both cancer cell and immune intrinsic biology.
This individual contributor role will spend 50% of their time performing cell culture of both adherent and suspension cell lines used in our mouse tumor models and 50% collaborating across groups to plan, execute and analyze preclinical mouse studies. A wide range of animal models including syngeneic, GEM, CDX, PDX and humanized tumor models are used.
The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work in a multi-functional team environment. You will gain and provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from target identification/validation, to IND enabling activities and ultimately to clinical Proof of Concept in patients. You will characterize and develop small and large molecule therapeutics in close collaboration with your colleagues within in vivo pharmacology and partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams.
Ideal candidate should have strong cell culture background, a wide variety of in vivo skills, and possess excellent communication skills with a strong commitment to scientific objectivity and excellence.
Cell culture of adherent and suspension cell lines for in vivo and in vitro use
Flow cytometry to ensure ectopic expression and immune cell populations
ELISA, CBA and similar assays
Conduct in vivo studies to evaluate targets, combination strategies, biomarkers and establish efficacy, PK/PD relationships.
Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates. Advanced in vivo cancer models include syngeneic, genetically engineered mouse (GEM) and humanized tumor models.
Compliance with IACUC and AALAC regulations.
Interpretation, documentation and presentation of experiments within a multidisciplinary team environment.
Qualifications and Requirements:
BS or MS in biology, immunology or a related discipline and expertise in the tumor microenvironment, oncogenic signaling pathways or immuno-oncology.
Industry and/or translational drug discovery experience is desired (min. 2-5 years).
Expertise in in vivo pharmacology and experience with animal models of human cancers.
Hands on in vivo skills (dosing, tissue/blood collection, surgery).
Experience with data capturing and analysis software (i.e. electronic notebook, StudyLog, PRISM, Excel, Flowjo).
Excellent interpersonal and communication skills to interact effectively with internal and external colleagues fostering a collaborative workplace environment.
Expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA, scRNAseq, organoids, is a plus.
Travel to local conferences is optional.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to firstname.lastname@example.org. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.