Principal Scientist I/II, Medicinal Chemistry

Schrödinger's mission is to revolutionize drug discovery through the use of breakthrough computational methods. We are currently looking for outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery programs.

Our drug discovery group of over 80 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, biologists and DMPK experts with experience working on all common target classes and therapeutic areas. We also engage with Contract Research Organizations (CROs) and Consultants. The group is supported by more than 100 software developers and engineers as well as a large scale compute infrastructure. Four of the programs we've worked on in the past seven years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA.

We are looking for experienced medicinal chemists who are passionate about applying cutting-edge computational approaches to drug discovery and would like to join our mission to improve human health and quality of life by transforming the way therapeutics are discovered.

Job title will be determined based on candidate experience and qualifications.

Responsibilities

• Key Medicinal Chemistry contributor to Schrödinger's drug discovery programs
• Responsible for support and execution of medicinal chemistry strategy to ensure the delivery of high quality clinical candidates
• Responsible for management of chemistry CRO's to meet project goals
• Work in close collaboration with computational chemists and modelers on new idea generation and evaluation using Schrödinger's computational drug discovery platform
• Contribute to evaluation of new target opportunities for Schrödinger's drug discovery portfolio

Essential Qualifications and Experience

• Ph.D. in synthetic organic or medicinal chemistry with 3-6 years of drug discovery experience in a pharmaceutical and/or biotechnology setting
• Extensive experience in working with external chemistry teams at CRO's
• Experience in structure-based drug design
• Contemporary knowledge of the key Medicinal Chemistry concepts and good understanding of biology, pharmacology, drug metabolism and pharmacokinetics
• Skilled at working in a dynamic multidisciplinary environment
• Excellent communication skills

Desirable Skills

• Experience in leading drug discovery projects
• Experience in progressing compounds from hit identification to clinical candidates
• Computational chemistry experience

Pay and perks:

Schrödinger understands it's people that make a company great. Because of this, we're prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Administrative and Human Resources departments also plan a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work for the past three years running.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, or sexual orientation. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.