Senior Scientist, Immunology

Location
Cambridge, MA, United States
Posted
May 31, 2021
Ref
R146
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia

As an Immunologist, you will join our ex vivo group, where we leverage top-notch CRISPR technology to fully unleash the power of cell-based therapy for autoimmune and Immuno-Oncology indications. You will be responsible for the design, implementation, and troubleshooting of experiments, both independently and in collaboration with colleagues, to reach desired goals. Other main responsilities include:
  • Establishing and performing in vitro/in vivo assays to support NK cell, TCR-T and CAR-T related projects
  • Using technical and literature knowledge to analyze and interpret results. Communicate research and development findings with internal and external teams/partners in a clear and concise manner
  • Contributing to scientific strategy of a project from theoretical knowledge and adapts experimental workflow
  • Coordinate and collaborate with colleagues to execute in vivo studies to assess CAR-T cell anti-tumor efficacy and safety using mouse model


About You

Are you an Immunologist with a strong interest in genomic editing and cell therapy? Our ideal candidate will have a PhD in Immunology, cell biology or related field with a solid background in immunology, especially in NK cell, TCR-T and CAR-T cell biology. If you describe yourself as a great team player who wants to have fun and grow with us, we encourage you to apply! Other desired skills include:
  • Ability to perform NK killing assay, FACS profiling assay, antibody-dependent cell-mediated cytotoxicity (ADCC) assay, CFSE proliferation assay, and mixed lymphocyte reaction (MLR) assay, multicolor flow cytometry, cytokine profiling assay by ELISA or MSD
  • Experience with CRISPR gene editing and lentiviral transduction / AAV insertion in primary T cells and primary NK cells
  • Experience with cell sorter to sort the desired cell population
  • Publication of original scientific work in peer-reviewed journal(s)
  • Experience in mentoring junior team member(s) and serving as a role model in the team is a plus


Meet your future team

The Allogeneic Cell Therapies team are a group of bright, fun and team-first individuals. Eager to move cool projects forward, we are motivated at the opportunity to make an impact for patients. The breadth of exposure to cutting edge gene therapy development will provide you with exposure to the full spectrum of gene and cell-based therapies, starting from CRISPR guides to patients who we try our best to support. Your future hiring manager is the Associate Director, Ex Vivo Cell Therapy. He oversees one of Intellia's high priority projects in the cell-based therapy space. Colleagues describe him as having infectious enthusiasm and an energetic attitude. Did we mention you'll be joining a team who just won the 2020 Intellia Annual IMPACT Award!

The team is currently working mostly onsite in a wet-lab environment. Therefore, we hope you are currently local to Cambridge MA, or open to relocating. While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for growth of scientists interested in a career in therapeutic biotechnology. If you join our team, you can expect to join fast, fun, exciting and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team together.

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.