Scientist, Cell Engineering

Location
South San Francisco, CA, United States
Posted
May 31, 2021
Ref
4828201002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is developing advanced delivery and genome engineering technologies to enable the next generation of cell and gene therapies. We are looking for a highly motivated and creative Scientist to join our new Cell Engineering group. The successful candidate will work with colleagues to establish novel genome editing capabilities and methods that will be used to develop engineered cells for our therapeutic programs. The environment is exciting and fast-paced and offers the opportunity to work and publish at the cutting edge of gene editing research.

DUTIES AND RESPONSIBILITIES
  • Identify reagents for efficient single and multiplexed gene editing to create Sana cell and gene therapies
  • Develop methods for the efficient delivery of gene editing reagents to diverse cell types for ex vivo and in vivo applications
  • Work with the group to establish and apply novel cell engineering capabilities
  • Coordinate with cross-functional teams to expand the range and sophistication of engineerable behaviors that can be applied to our cell therapy programs
  • Generate knock-out and knock-in critical cell lines using gene editing tools
  • Verify editing via sequencing methods (Sanger/NGS) and functional assays such as flow cytometry, western blotting, qRT-PCR, microscopy
  • Work closely with development teams to adapt reagents, assays and methods to clinical manufacturing
  • Assist in production and purification of viral vectors
  • Communicate and document findings via verbal and written methods

QUALIFICATIONS

Basic Qualifications
  • PhD +2 years of academic/industry experience or BA/MS +7 years academic/industry experience
  • Proficiency in the culture and editing of diverse mammalian cell types
  • Strong scientific background and publication record with proven high levels of performance
  • Excellent communication skills; ability to present effectively to teams with diverse backgrounds
  • Ability to adapt to increasing scope and complexity of work as projects mature
  • Comfortable in a fast-paced research environment with minimal direction, and able to adjust workload based upon changing priorities
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications
  • Experience in the production of viral vectors including lentivirus and AAV
  • Familiarity with viral vector titering methods including ELISA for viral proteins like p24 and flow cytometry to measure transduction of target cells with GFP
  • Demonstrated high throughput and multiplexing capabilities
  • Expertise in multicolor flow cytometry and FACS sorting
  • Experience with assays for measuring cellular DNA damage response
  • Molecular biology skills


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.