Scientist, Phage Display, Antibody Discovery

New York, NY, USA
May 30, 2021
Required Education
Bachelors Degree
Position Type
Full time
Company Description:

Molecular Templates is a clinical-stage biopharmaceutical company focused on the discovery and development of differentiated, targeted, biologic therapeutics.

Our proprietary biologic drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer and other serious diseases. MTEM currently has multiple clinical-stage ETB candidates in development including MT-5111, TAK-169, and MT-6402. Additional preclinical compounds derived from our ETB platform technology are being advanced toward clinical development.

Additional information about Molecular Templates can be obtained at

Position Overview:

MTEM is seeking a highly motivated individual to help build an antibody discovery group. This hands-on position involves generation and screening of antibodies to be used in the company's ETB scaffold for the development of novel therapeutics. The Scientist will join a team of scientists to support therapeutic antibody discovery programs which focus on cancer. This position requires experience with phage display library construction and panning, antibody screening, expression, and optimization. This role will be located onsite in our Manhattan, NY office (Financial District).

Job Responsibilities:
  • Designs and executes phage display library selections for lead identification of antibodies against challenging targets
  • Builds and validates immune phage display libraries
  • Performs high throughput screening of phage panning output
  • Analyzes antibody sequence data (Sanger and/or NGS)
  • Keeps a detailed and well-organized laboratory notebook
  • Presents data at group meetings
  • Stays current with literature and emerging trends in the discipline
  • Performs other related duties as assigned

  • PhD in Immunology, Microbiology, Biochemistry or related field
  • 2+ years of experience in an antibody discovery environment or
  • Master's Degree and a minimum of 4 years of experience in antibody generation in an academic laboratory, or in the pharmaceutical and/or biotechnology industry
  • Demonstrated successful track record with phage display library construction and panning
  • Hands-on experience with whole cell panning techniques
  • Working knowledge of high-throughput phage panning processes (e.g. semi-automated panning on the Kingfisher system and/or colony picking and sample processing on a QPix system)
  • Proficiency in molecular biology techniques (PCR, cloning, primer design, plasmid preparation, etc.)
  • Use of DNA sequence analysis/editing using tools such as Geneious or DNAStar
  • Handling and manipulation of bacterial cultures
  • Enzyme-linked immunosorbent assay (ELISA) development
  • Experience with affinity maturation via phage display strongly desired
  • Experience with B cell cloning a plus
  • Ability to work on multiple projects in parallel to deliver results in rapid timeframes
  • Ability to work independently in a dynamic environment
  • Critical thinking, prioritization of tasks, attention to detail and troubleshooting
  • Creativity in approaches to complex problems and desire to expand technical skillset
  • Timely delivery of team goals and ability to build productive relationships with colleagues across MTEM's R&D department

Reporting Structure:

This position currently has no supervisory responsibilities. This position reports to the Director, Antibody Discovery.

Molecular Templates celebrates and supports our differences and is proud to be an Equal Employment Opportunity employer. We do not discriminate based upon race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, veteran status, disability, or any other legally protected characteristic. 

MTEM is committed to providing reasonable accommodations for qualified individuals. If you need assistance with your application due to a disability, you may contact us at:

By submitting a resume for consideration, applicants verify that they have read MTEM's Applicant Privacy notice.

Molecular Templates Inc