Associate Director, Liver Disease Biology

Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia

As an Associate Director, Liver Disease Biology, you will be j oi n ing a company where we a re applying CRISPR/Cas9 genome editing and gene therapy technologies for therapeutic benefit. In your role as an Associate Director, you will oversee the advancement of our liver disease projects , bringing novel drug candidates with high potential for efficacy in humans into the early-stage pipeline. You will generate key data for evaluating mechanism of action and/or drug candidate efficacy and pharmacodynamics. Other main responsi bilities include:

• Leading a cross-functional, disease-focused project team from initiation to DC stage .
• Developing in vitro assays to interrogate biological processes and test novel therapeutics .
• Performing cell culture with rodent, primate, and human primary cells and cell lines .
• Delivering high quality data to help advance drug discovery projects in the therapeutic portfolio .
• Generate new therapeutic hypotheses leveraging CRISPR/Cas9 gene editing .
• Propos ing and develop ing innovative methodologies and technologies for project development.
• Present ing data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community .
• Act ing as a scientific mentor .

About You

Are you a scientific leader with deep subject-matter expertise in liver disease biology? Candidates interested in applying should have a PhD in C ell B iology , B iochemistry, or related field . The ideal candidate will also have experience in drug discovery or target validation research . If you consider yourself a strong communicator and enjoy managing a team , we encourage you to apply ! Other qualifications include:

• Experience of leading a diverse project team to successfully achieve objectives
• Deep knowledge of animal models of liver disease including both hepatic and extrahepatic cmodels
• Cell culture, including with primary human cell types
• qPCR/ ddPCR , Western blotting, ELISA
• Bioassay development, optimization and validation
• Experience with CRISPR/Cas9 technology
• Knowledge of inherited diseases of the liver, nervous system, bone marrow, and/or muscle

Meet your future team

The Disease Biology team is a group of bright, fun an d team-first individuals. Your future hiring manager is the Vice President, Disease Biology. Having spent nearly 6 years with Intellia, the hiring manager is very knowledgeable on the company's history and mission . Your future team is a group of dedicated individuals, driven to change patients' lives. As we build our team, we're excited to work with people who share our commitment and energy to making a difference.

The team is currently working mostly onsite. Therefore, we hope you are currently local to Cambridge MA, or open to relocating. While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for growth of scientists interested in a career in therapeutic biotechnology. If you join our team, you can expect to join a fast, exciting , and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team together.

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.