Associate Director, Preclinical Pharmacokinetics

Location
San Diego, California
Posted
May 29, 2021
Ref
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Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time

Company Overview

 Avidity Biosciences is pioneering a new class of oligonucleotide-based therapies called AOCs designed to overcome the current limitations of oligonucleotide therapies in order to treat a wide range of serious diseases. We utilize our proprietary AOC platform to design, engineer and develop therapeutics that combine the tissue selectivity of monoclonal antibodies (mAbs) and the precision of oligonucleotide-based therapies in order to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. We are passionate about the impact of every employee in bringing these potentially transformative therapeutics to patients in need. Make a difference with us.

Essential Duties and Responsibilities

• Design, plan, monitor and conduct preclinical pharmacokinetic studies to support drug candidate nomination and early preclinical drug development activities in-house and at contract research organizations

• Interpret preclinical pharmacokinetic data to inform the design of preclinical pharmacology and GLP toxicology studies

• Partner with clinical pharmacology on PKPD modeling activities to estimate efficacious dose and exposure range to support dose selection in toxicology studies

• Partner with DMPK to identify, design and plan appropriate assays for ADME characterization for oligonucleotide-based drug candidates

• Serve on research project teams as preclinical pharmacokinetics representative 

• Draft pharmacokinetic and bioanalytical sections of regulatory documents 

Qualifications

To perform this role successfully, an incumbent must be able to perform each essential duty satisfactorily. The preferred requirements listed below are representative of the skills, knowledge, and/or abilities required.  Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions.

Education:

• PhD degree in pharmaceutics, biochemistry, pharmacokinetics, pharmacology, or related discipline

Requirements:

• 3+ years experience in the biotech/pharmaceutical industry in the area of preclinical drug discovery and/or development

• Experience in the conduct, analysis and interpretation of in vivo preclinical pharmacokinetic studies

• Experience with large molecule (monoclonal antibody) and/or oligonucleotide therapeutic modalities 

• Experience with characterization of ADME properties of drug candidates

• Familiarity with large molecule bioanalytical assay development desired

• Must be detail oriented with strong documentation and organizational skills

Additional Requirements:

• Excellent interpersonal skills, ability to work in a matrix environment and develop relationships with key stakeholders.

• Excellent communication and presentation skills to efficiently relay information to project teams and other key stakeholders

Strong research background and interest in understanding PK/ADME data in the context of complex biology

• Proven ability to work independently and be self-motivated