Scientist, mAb Discovery

San Diego, California
May 29, 2021
Biotech Beach
Required Education
Position Type
Full time

Company Overview

Avidity Biosciences is pioneering a new class of oligonucleotide-based therapies called AOCs designed to overcome the current limitations of oligonucleotide therapies in order to treat a wide range of serious diseases. We utilize our proprietary AOC platform to design, engineer and develop therapeutics that combine the tissue selectivity of monoclonal antibodies (mAbs) and the precision of oligonucleotide-based therapies in order to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. We are passionate about the impact of every employee in bringing these potentially transformative therapeutics to patients in need. Make a difference with us.

Job Summary

We are seeking a Scientist to join the New Targets team at Avidity Biosciences. The main objective for this position will be to aid in the expansion of our AOC platform and to leverage our technology into new therapeutic areas. The ideal candidate will have an innovative and curious attitude, a scientific mindset, and a desire to improve patients’ lives through technology. The candidate should also be flexible and adaptable to the evolving nature of a rapidly expanding company and department.

Essential Duties and Responsibilities
  • Developing and performing in vitro cellular assays with human and rodent cells. Hands-on experience in proliferation, agonistic/antagonistic receptor assays, luciferase, fret, phosphorylation, and or other reporter assays in a high throughput context are preferred
  • Proficient in monoclonal antibody characterization and engineering techniques such as affinity ranking, epitope mapping, and affinity maturation
  • Hands-on experience with monoclonal antibody generation is required. Experience with human transgenic antibody platforms with multiple immunization strategies and single-cell B cell isolation is desired.
  • Experience with RNAscope, spatial genomics, and histology is a plus
  • Ability to design, perform and interpret complex experiments
  • BS (10+ years of experience), MS (5+ years of experience) or PhD in Bioengineering, Biology, or related discipline
  • Ability to conduct self-directed research and to work effectively in a dynamic environment with a diverse team of coworkers
  • Solid written and oral communication skills, enthusiasm, integrity, exceptional problem-solving skills, self-motivation, strong interpersonal skills, and attention to detail are necessary
  • Ability to manage multiple projects and collaborations both internal and external