Scientist, Antibody Drug Conjugate (ADC) Formulation Development

Location
Tarrytown, NY, United States
Posted
May 29, 2021
Ref
25106BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Regeneron's Formulation Development Group is seeking a Scientist as we work to support formulation and drug product development at all stages of product development and commercialization supporting different drug product modalities. In this role, you will carry out characterization and development studies on antibody and antibody conjugated molecules to support drug product design and development. In addition, you will be involved in applying biophysical and biochemical methods to support developability assessment of lead biological drug molecules.

A Typical Day in the Role of Scientist Might Look Like:
  • Design and execute formulation development and characterization studies as well as stability studies to support formulation and drug product platform development for different modalities (e.g. antibodies, fusion proteins, and conjugates).
  • Lead the development of phase-appropriate biochemical and biophysical methods as well as high-throughput biophysical methods for characterization of stability and degradation mechanisms of the drug products.
  • Develop timelines, setup sample testing plan, coordinate with cross-functional team members to support critical program activities and meet key results.
  • Author/review technical documents, such as study protocols, technical reports and technology transfer documents to internal and external collaborators, including CROs and CDMOs, to support the process development and manufacturing of clinical drug substances and drug products.
  • Contribute to regulatory documents, response and submission.
  • Serve as a team representative and/or subject matter of specialist (SME) at the cross-functional research and product development teams, such as Research Working Groups and CMC teams.
  • Lead or participate in research studies for product characterization and evaluation of state-of-the-art new technology platforms driving technology innovation.
  • Establish internal and external influence through presentations and publications.
  • Participates in the general lab and instrument maintenance.

This Role Might Be For You If:
  • You have strong initiative and drive to complete results-oriented tasks and learn new technologies related to formulation development.
  • You are capable of multi-tasking, working both independently and within a team environment.

This role requires a Ph.D. in Biochemistry, Biophysics, Chemistry, Pharmaceutical Science or a related field with 0-4 years of industry or academia working experience. Hands-on experience and trouble-shooting proficiency with biochemical, biophysical and protein structure techniques, such as HPLC, CE, DLS, Mass spectrometry, protein NMR, X-ray crystallography. Research experience in Protein Chemistry, Structure Biology and Biophysics are desired. Experience with biophysical characterization of protein-protein interactions, such as opalescence liquid-liquid phase separation, and viscosity is a plus. Experience in Computational Chemistry or structural modeling and bioinformatics is also a plus. Ability to prioritize and manage multiple projects/tasks. Must be self-motivated, great teammate with good oral and written communication skills.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.