Scientific Research Investigator
- Implement and conduct biochemical, pharmacological, physiological, and behavioral components of experimental investigations in collaboration with the principal investigator.
- Read, understand, and execute techniques, procedures, and plans to meet requirements of quality standards, national standards of research technical accuracy, other relevant written guidelines, and timelines prescribed by the research plan and based on professional judgment.
- Weigh laboratory animals and record data in laboratory notebook. Animal weights and physical condition shall be tracked. Feed shall be adjusted to conform to desired growth curves and/or as dictated by experimental manipulations or feeding conditions (e.g., fasting).
- Utilize auto shaping, timing schedules, simple and complex schedules of reinforcement and discrimination and reaction-time behavioral cognitive tasks to prepare naïve animals for behavioral evaluation of toxicity; assess normal and toxicity-impaired behavior in small animals; assess the short and long-term safety and efficacy of medical countermeasures; conduct operant behavioral training and shuttle box avoidance session to include routine testing; and conduct preventive cleaning and maintenance of testing apparatus.
- Perform accurate calculation and administration of medications or other substances by injection, orally, or topically; anesthetic monitoring, and surgical procedure assistance; collection of blood and other biosamples; creating entries in medical records, conduct of health checks, performance of handling and restraint of animals, and surgical suite maintenance.
- Serve as a chemical agent operator or buddy for pharmaceutical based agent and will prepare and dilute agents, administer agents to laboratory animals by intramuscular, subcutaneous, intravascular or oral methods; decontaminate, dispose and properly turn-in agent waste; administer by intramuscular, subcutaneous, intravenous or intraperitoneal route candidate therapeutic compounds; and operate a satellite waste accumulation site in the laboratory.
- Evaluate dose, route, frequency and combinatorial response of medical countermeasures against chemical, pharmaceutical and other toxins.
- Observe for and record in laboratory signs of intoxication when they occur in the experimental animals and time of death in experimental animals which have been exposed to chemical agents.
- Implement an enrichment plan consistent with institutional standards and in support of protocol needs; assess NHP social environment and hierarchy to maximize beneficial social partnership/pairing of animals; and oversee implementation and administration of birth control methods as appropriate; pair/separate animals as dictated by research protocols, or experimental and feed schedule.
- Oversee and conduct an NHP training program to assess behavioral competence and compliance, to include pole and collar/chair training, biosampling, squeeze and restraint training, and injection tolerance; conduct operant behavioral panel testing to include calibration, maintenance, parameter optimization, and sanitization.
- Perform solubility studies of novel candidate therapeutic compounds and reactivators IAW MRICD SOP; evaluate dose, route, frequency and combinatorial response of medical countermeasures against chemical, pharmaceutical and other toxins; assess animal health and behavior for safety and efficacy of novel candidate therapeutic compounds following administration by intramuscular, subcutaneous or intravenous routes; record findings in laboratory notebooks during or immediately following the experiments.
- Perform surgical implantation of physiological telemetric devices.
- Record, interpret and analyze small and large animal telemetry and physiology data.
- Provide quarterly written updates including text, tables, graphs, statistical results, interpretation of results and conclusions for use in laboratory notebooks, manuscripts, and reports.
- Guides laboratory technicians in the appropriate collection and storage of experimental data.
REQUIRED SKILLS AND EXPERIENCE:
- Minimum 8 years of direct research experience in small animals. Experience must include behavioral assessment and biosampling.
- Must be experienced with regulated toxicology/pharmacology studies and must possess at least 5 years of experience working with small animals in a behavioral toxicology/pharmacology research setting.
- Must have direct research experience in non-human primates to include behavioral assessments.
- Ability to work independently or with others.
- Must have experience establishing and overseeing a behavioral-physiological testing laboratory, performing pharmacological assessments, publishing manuscripts, and must be certified, or capable of obtaining certification, to work with nerve agents.
- Must be proficient with Sigmaplot and SPSS.
- Knowledge of basic computer programs (i.e., word processing, spreadsheets, and reference management programs) and have the capacity to learn specialized computer programs for collection of behavioral data.
- Experience in cognitive-behavioral assessments and operant behavioral training for NHP’s and small animals.
- Must have a Ph.D. in psychology, biology, Pharmacology, Neuroscience or a related research area from an accredited university.
CITIZENSHIP/SECURITY CLEARANCE REQUIREMENTS:
Laulima Government Solutions, LLC is a fast-growing government service provider. Employees enjoy competitive salaries; a 401K plan with company match; medical, dental, disability, and life insurance coverage; tuition reimbursement; paid time off; and 10 paid holidays. Laulima Government Solutions, LLC is proud to be an equal opportunity employer.
We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. We are proud to state that we do not discriminate in employment decisions on the basis of race, color, religion, sex, pregnancy, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status. If you are a person with a disability and you need an accommodation during the application process, please click here to request accommodation. We E-Verify all employees.
The Alaka`ina Foundation Family of Companies (FOCs) is comprised of industry-recognized government service firms designated as Native Hawaiian Organization (NHO)-owned and 8(a) certified businesses. The Family of Companies (FOCs) includes Ke`aki Technologies, Laulima Government Solutions, Kūpono Government Services, and Kapili Services, Po`okela Solutions, Kīkaha Solutions, LLC, and Pololei Solutions, LLC. Alaka`ina Foundation activities under the 501(c)3 principally benefit the youth of Hawaii through charitable efforts which includes providing innovative educational programs that combine leadership, science & technology, and environmental stewardship.
For additional information, please visit www.alakainafoundation.com