Senior Scientist, Cell Therapy Process Development

Location
Gaithersburg, MD, United States
Posted
May 28, 2021
Ref
1707910203
Hotbed
BioCapital
Required Education
Bachelors Degree
Position Type
Full time
About MaxCyte:

MaxCyte, the clinical - stage global cell - based therapies and life sciences company, uses its proprietary next - generation cell and gene therapies to revolutionize medical treatments and ultimately save lives. The Company's premier cell engineering enabling t echnology is currently being deployed by leading drug developers worldwide, including all of the top ten global biopharmaceutical companies. MaxCyte licences have been granted to more than 1 4 0 cell therapy programs, with more than 100 licensed for clinical use, and the Company has now entered into ten clinical/commercial license partnerships with leading cell therapy and gene editing developers. MaxCyte was founded in 1998, is listed on the London Stock Exchange (AIM:MXCT, MXCL) and is headquartered in Gaithersburg , Maryland, US. For more information, visit www.maxcyte.com .

Job Summary:

The Senior Scientist , Cell Therapy Process Development position plays a key role in implementing and optimizing processes related to the development of cellular therapies involving ex vivo engineering of primary immune cells and stem cells via flow electroporation . This individual will work independently to optimize cell isolation and culture protocols, develop assays, and integrate cell culture platforms and analytical technologies into a GMP - compliant workflow for non - viral cellular engineering. We are seeking a flexible self starter with the breadth of professional experience and drive to work effectively with both internal and external partners in a highly matrixed and cross - functional organization.

Job Responsibilities:

• Leads the establishment of a PD lab, including installation of equipment and the implementation of lab SOPs
• Supports cross - functional projects with biological scientists, mechanical/electrical engineers, and marketing/business development stakeholders
• Participates in internal and external collaborations to evaluate and implement new process technologies
• Improve s non - viral cell engineering processes through designed experiments using innovative approaches
• Perform s analytical assays to drive data collection for process development experiments
• Maintains up to date knowledge of cell therapy manufacturing trends and provides recommendations regarding manufacturing process improvement initiatives
• Develop s , revise s, and review s SOPs, protocols , and process development and technical reports
• C omplies with all applicable laws and Company policies regarding health, safety, and environment.

Job Requirements:

• PhD in immunology, cell biology, biochemistry, biology, bio or chemical engineering, or a related discipline with at least 5 years of hand s- on experience in the cell therapy sector of the biopharmaceutical industry or a minimum of 10 years re levant experience with a master's degree.
• Excellent understanding of mammalian cell biology and metabolism
• Experience with cell processing techniques, cell culture methods for preparation of therapeutic cells, and cell separation technology, including product process optimization for multiple primary cell types (PBMCs, T cells, NK cells, stem cells, etc.)
• Expe rience with manufacturing scale processes using various cell culture platforms (e.g. Cell Factories, G - Rex's, Bioreac to rs, etc.) and equipment (CliniMACS, Sepax , LOVO etc.)
• Significant experience in engineered cell therapies with special emphasis on non - vi ral methods
• Thorough knowledge of cGMP manufacturing, process automation and technology transfer
• Extensive experience with analytical methods for cell and gene therapy, including in depth knowledge of flow cytometry and test methods, such as qRT - PCR and i mmunological assays
• Ability to independently conceive experimental designs, make detailed observations, analyze and interpret data, propose improvements to and troubleshoot experimental protocols
• Strong quantitative, qualitative, and critical thinking skills and abilities. Ability to adapt to changing needs as experiments develop or priorities change
• Detail oriented with strong organization and project management capabilities
• High energy level and a positive outlook coupled with the requisite "can do" attitude
• Strong written and oral communication skills are essential; ability to present thoughts clearly and concisely
• Ability to effectively collaborate with and lead vendors, customers, colleagues, and direct reports across teams. Ability to quickly adapt to a rapidly changing environment and demands
• Demonstrated computer skills; experience using MS Office and other data analysis software and other related applications . MaxCyte, Inc. is an equal opportunity employer.