Scientist: Immunology

Pasadena, CA, United States
May 28, 2021
Science/R&D, Immunology
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Company Overview: Terray Therapeutics is a venture-backed biotechnology company leveraging our vast high-quality data to optimize the path from discovery to transformative therapeutics. Our approach delivers on the promise of computation to revolutionize drug discovery. Through our closed-loop wet lab discovery platform and data-rich AI, we overcome existing constraints on chemical data by systematically mapping the biochemical interactions of massive and diverse small molecule libraries to identify novel therapeutic compounds. Access to this quantitative data at scale allows us to intelligently navigate an infinitely extensible and highly diverse chemical space to efficiently design, discover and optimize small molecule therapeutics. Our internal development programs are focused on immunology. In addition to these programs we also work with leading pharmaceutical companies.

Our integrated computational platform, tNova, harnesses our novel affinity binding technology, tArray, unique resynthesis capabilities, and broad biology infrastructure. tArray is the foundation of our discovery engine. It enables us to screen hundreds of millions of compounds in minutes and return quantitative data on each compound. Vast, high purity, and high diversity compound libraries are rapidly iterated using best-in-class chemistry to unlock chemical insights at the scale necessary to power AI-driven drug discovery.

Position Summary: Terray Therapeutics is seeking a highly motivated, creative, and experienced immunologist to join our biology team. The candidate will play a key role in the evaluation of therapeutic targets for immune modulation. The candidate will be responsible for designing and optimizing a wide-range of biochemical and cell-based assays to profile hits from our screens for lead optimization. The candidate will work with CROs to evaluate lead compounds in PK and disease models. The position will report to the Head of Biology.

The core responsibilities of this job will be
  1. Evaluate new therapeutic targets for inflammation/autoimmunity with a focus on project design from in vitro screening through disease models
  2. Independently design and optimize biochemical and cell-based assays specific to therapeutic targets of interest
  3. Adapt assays for medium to high-throughput screening of small molecule hits from our affinity screens
  4. Design and execute studies to fully characterize the mechanism of action of small molecules
  5. Analyze data and communicate results in our project team meetings
  6. Work closely with scientists across the company in chemistry, platform, screening and data teams to efficiently move projects forward
  7. Work with CROs to run in vivo PK, disease model and toxicology studies as needed
  8. Help evaluate and set up new lab instrumentation
  9. Support organization of lab and equipment as needed

Experience and Qualifications: Given the company's size, anticipated growth and fast-paced environment, the organization requires a Scientist who is thoughtful, high energy and can partner with the broader organization to further enhance our next generation drug discovery capabilities.

Part of Terray Therapeutics' success is nurtured by a hands-on work environment where everyone is accountable, everyone is vested in a vision of excellence, and everyone actively takes part in the success of the business. Terray Therapeutics supports a positive work environment comprised of engaged employees who feel appreciated, recognized and free to be creative.

Qualifications include:
  • PhD with 5+ years of academic/industry research experience in the field of immunology or immuno-oncology
  • In-depth knowledge of autoimmune and inflammatory disease models is a plus
  • Background in small molecule drug discovery strongly preferred
  • Extensive hands-on experience with standard immunological assays including primary cell isolation and culture, flow cytometry, cytokine detection and gene expression analysis required
  • Experience with screening small molecules in medium through-put cell-based assays and small molecule mechanism of action studies ideal
  • Experience with molecular biology techniques and cell line construction a plus
  • Excellent organizational, interpersonal and communication skills and can thrive in a highly collaborative research environment
  • Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data

She/he will exhibit the ability to work well under pressure to provide results in a short timeframe. The company is looking for a highly responsive, goal-oriented individual who will bring significant energy and drive to solve complex technical problems and help us achieve our mission to advance human health.