Scientist, Gene Therapy RNAi

Location
Tarrytown, New York, United States of America
Posted
May 28, 2021
Ref
25062BR
Required Education
Associate Degree
Position Type
Full time
We are seeking a Scientist within the Formulation Development Group of Regeneron Pharmaceutical Inc. at Tarrytown, NY. Our Scientist will be involved with clinical and commercial formulation and drug product development activities including protein stability and characterization. The Scientist will also support manufacturing process development, gene therapy modalities, and drug delivery technologies.

A Typical Day in the Role of Scientist Might Look Like:
• Leads and participates in drug product development and stability assessment activities that may include candidate screening and selection for preclinical and Phase 1 clinical studies, and developing formulations for Phase 2/3 clinical studies and commercialization including assessment and selection of primary container closure system such as pre-filled syringes.
• Develop drug product formulation for diverse set of modalities such as mAbs, mAb-like proteins, siRNA, ASO, AAV, and/or Lipid Nanoparticles (LNP).
• Directly leads or indirectly guides Research Associates in conducting research and developmental work, and investigating and solving developmental problems. Sets goals, assigns tasks, and provides performance management and development as needed.
• Independently designs, writes, executes and documents stability studies and other experiments to support stability testing and understand quality attributes to support formulations and stability
• Develops and uses analytical methods to support formulation development and stability testing of mAbs, siRNA, AAV, LNP, and other modalities.
• Seeks out, recognizes and assesses new technologies to improve formulation development and analytical characterization
• Presents work at group, department and inter-department meetings, serves as a team representative in drug development team meetings, and shares knowledge and expertise of formulations development at cross-functional team meetings
• Authors and reviews formulation development sections of regulatory and technical documents, study reports and technology transfer documents
• Collect, process and document data by following the organizational standard methodologies and policies.
• Utilizes statistical knowledge and software packages (e.g. JMP) for study design and data analysis.
• Keeps updated on the latest scientific findings by reading peer-reviewed science journals, and attending and presenting at relevant scientific conferences

This Role Might Be For You If:
• You have an excellent problem-solving approach
• You thrive in a creative, flexible team environment

This role requires a Ph.D. with 0-5+ years post-doctoral or proven industry experience in Pharmaceutical Sciences, Biochemistry, Biophysics, Chemistry, Biomedical Engineering, Chemical Engineering, or a related field. Expertise in protein and/or gene therapy research and characterization, with keen analytical and problem-solving skills. Relevant hands-on experience with proteins (mAb, mAb-like proteins) and viral/non-viral gene therapy modalities (siRNA, LNP, ASO, AAV, etc.) preferred. Excellent oral and written communication skills are required. Publications in the field preferred. Possess an ability to grasp the big picture and able to recognize subtle trends in data. Strong technical knowledge base and meaningful experience with protein/peptide/nucleic acid chemistry, biophysical/biochemical characterization of proteins and gene vectors, bioanalytical method development and biomolecule product development. Experience with chromatography methods (HPLC, UPLC, column chromatography), visible and subvisible particle analysis, capillary electrophoresis and/or biophysical techniques (UV-vis, DLS, CD, FTIR, DSC, AUC, Fluorescence, Raman spectroscopy) for protein/gene vector characterization. Enthusiasm for science with a motivation for making contributions in a team environment is vital. Ability to quickly adapt to changes in program direction.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.