Associate Scientist, Antibody Discovery - Phage Display

Location
Seattle, WA, United States
Posted
May 26, 2021
Ref
1847714528
Hotbed
BioForest
Required Education
Bachelors Degree
Position Type
Full time
Just is seeking a highly motivated and creative Associate Scientist that desires a significant opportunity to help invent the technologies required to improve worldwide access to biotherapeutics. This position will be part of a cross-disciplinary team developing antibody libraries for discovery, therapeutic optimization, and high throughput characterization. The successful candidate will support the invention, design, and implementation of phage display library methods to drive biotherapeutic development. A strong foundation in molecular biology and vector cloning is required for this position, with additional experience in phage display and/or bacterial protein expression strongly desired. This individual must also possess strong communication and collaboration skills, a desire to learn new scientific concepts and domains, and an ability to work directly with scientific staff across multiple disciplines.

Responsibilities:
  • Work independently and in teams to develop, implement, and utilize antibody phage libraries
  • Design and construct expression vectors using standard methodologies, such as PCR, Gibson Assembly, and ligation
  • Analyze Sanger DNA sequences
  • Perform biopanning against protein targets
  • Perform mammalian cell culture and transient protein expression
  • Characterize phage-derived candidates via ELISA and/or other in vitro assays
  • Maintain a detailed and organized record of experiments in an electronic notebook
  • Organize, summarize, and present data and results at department and project team meetings

Qualifications and Education Requirements:
  • S. degree in life sciences, cellular/molecular biology, or other related discipline with 1-5 years of experience
  • Thorough working knowledge of standard molecular biology techniques (cloning, PCR, site-directed mutagenesis, Sanger sequencing, plasmid isolation)
  • Hands-on experience in vector cloning, including primer design
  • Experience working with DNA analysis software programs, such as Geneious, SnapGene, or Sequencher
  • Excellent verbal and written communication skills
  • Strong focus on quality and attention to detail
  • Possess effective task/time management organizational skills
  • Ability to work in small groups as well as independently

Preferred Qualifications:
  • Experience in phage display techniques
  • Experience in library design and construction
  • Experience with mammalian cell culture and transient protein expression
  • Experience with NGS library construction and data analysis is strongly desired

About Just - Evotec Biologics

Just - Evotec Biologics, wholly-owned by Evotec SE, is a unique platform company that integrates the design, engineering, development, and manufacture of biologics. With deep experience in the fields of protein, process and manufacturing sciences, the Just team came together to solve the scientific and technical hurdles that block access to life-changing protein therapeutics; from the design of therapeutic molecules to the design of the manufacturing plants used to produce them. Just's focus is to create access and value for a global market through scientific and technological innovation. Our state-of-the-art labs and cGMP clinical manufacturing plant are co-located in Seattle's South Lake Union neighborhood - the center of Seattle's medical, global health, and technology industries and a noted top emerging life science hub in the U.S. Our fast-growing team of 200 employees is expanding Just's innovative platform and footprint - building our first North American J.POD® commercial manufacturing facility in the Seattle area. For job opportunities, learn more at www.just.bio/careers