Principle Research Associate/ Research Scientist, Analytical Chemistry

South San Francisco, California
May 26, 2021
Biotech Bay
Required Education
Associate Degree
Position Type
Full time

About IDEAYA Biosciences:

IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We are applying these capabilities across multiple classes of precision medicine, including direct targeting of oncogenic pathways and synthetic lethality – which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response.

IDEAYA recently announced a landmark strategic partnership with GSK in Synthetic Lethality for certain pipeline programs. The GSK partnership is transformative and enables IDEAYA and GSK to collectively build an industry leading platform and pipeline in Synthetic Lethality. For more information, please see

Position Summary:

The Principle Research Associate / Research Scientist in Analytical Chemistry / CMC is highly knowledgeable, skilled and experienced in a broad range of analytical techniques and will participate in cross-functional team support to advance our drug discovery and development pipelines.


What you’ll do:

  • Participate in the Analytical Chemistry / CMC efforts in facilitating internal drug discovery and early development programs by executing physiochemical / in vitro ADME studies, compound purification, and structural elucidation
  • Troubleshoot methods and provide technical guidance across discovery and development programs
  • Manage maintenance of lab analytical equipment
  • Train and supervise research associate and scientists to ensure proper execution of analytical experiments
  • Assist with coordination of CMC aspects of the analytical development program with other functional areas
  • Assist in performing vendor and CMO review and selection; and assist in providing oversight of analytical aspects of manufacturing, including development and justification of specifications, analysis of release data, and investigation/resolution of OOS events at CMOs
  • Ensure analytical method qualification/validation/technical-transfer documentation (test protocols, methods, and reports) are relevant, accurate, and complete
  • Develop stability protocols, review stability data, and manage stability programs in conjunction with Quality
  • Ensure provision of the relevant CMC sections for INDs/IMPDs and their updates

  • Required Experience/Education:
    • Ph.D. in analytical chemistry or related discipline with minimum of (5) years or M.S. with minimum (10) years of drug discovery/development or related experiences and demonstrated ability in cross-functional team support
    • Strong subject matter expertise in in vitro ADME / physiochemical properties, small molecule purification, structural elucidation, multidisciplinary chemical analysis, analytical method development/validation, and CMO participation

    Knowledge, Skills and Abilities:
  • Exceptional problem-solving skills and ability to quickly adapt and shift focus as needed
  • Excellent interpersonal and communication skills for internal and external collaborations
  • Ability to multi-task in a fast-paced dynamic environment while demonstrating a calm and positive attitude and a superior work ethic
  • Ability to mentor junior level associates and scientists, including direct reports or supporting team members
  • Benefits

    When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

    Ideaya is an equal opportunity employer. In accordance with applicable law, Ideaya does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.