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Senior Research Associate Potency Assays

Employer
Intellia Therapeutics
Location
Cambridge, MA, United States
Start date
May 23, 2021

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Discipline
Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown

Job Details

Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How You Will Achieve More with Intellia:

We are excited to welcome this new member to our growing team and company. This is both a strategic and hands-on role. If you are a strong and independent problem-solver, agile, detail-oriented with a strong technical background in cell culture, analytic development, and potency assays, and enjoy working in cross-functional teams, this is the role for you! As a Senior Research Associate, you will work on various activities including:
  • Develop, optimize and in-house qualification of cell-based potency assays and characterization assays.
  • Conduct experiments independently and in collaboration with colleagues in support of project goals. Compile and present data to support analytic development, process development, and stability studies.
  • Act as subject-matter-expert throughout tech transfer of analytical methods.
  • Participate in routine laboratory operations including coordinating with internal PD and cGMP manufacturing on sample testing, maintaining laboratory equipment, and maintaining laboratory sample and reagent inventory.
  • Evaluate novel assay technologies and methodologies for use in development or improvement of analytical methods.
  • Author and review SOPs, and development reports, and assist in the preparation of CMC regulatory submissions.
  • Work collaboratively with Analytical Development, Process Development and Quality teams to gather and analyze data to achieve method readiness
  • Maintain well documented records of analytical data, laboratory notebooks, execution of assays and stability data


This is a unique role that will provide you with opportunities to impact ex vivo and in vivo applications by:
  • Developing, potency assays for cellular drug products, CRISPR/Cas9 components, lipid-nano particles, and AAV.
  • Collaborate with Intellia's cross-functional platform development team and build the bases to define and optimize and qualify potency and characterization assays.
  • Work to tech transfer assays to external testing labs.


About You:
  • MS in Chemistry, Biochemistry, Biotechnology or related field with 0-2 or more years of experience in an industrial setting; or BS in Chemistry, Biochemistry, Biotechnology or related field with 2+ years of experience in an industry setting.
  • Experience with primary culture of cell lines and primary cells, cell-based functional assays, and multi-color flow cytometry. Experience in designing and qualifying analytic test methods for cell-based therapies.
  • Direct experience in Analytical Development, Quality Control, or Process Development is a plus.


Meet Your Future Team:

The Potency Analytical Development team is a highly motivated and lively group with an innate curiosity to learn. You will report to the Associate Director, Potency Analytical Development. This team leads various important elements of the Technical Operations (CMC) department, including design of potency and characterization assays for in vivo and ex vivo drug products and drug product components.

Although Intellia currently is a partially virtual environment, the Human Resources team and Cultural Ambassadors have made it a priority to continue to foster a sense of community among the group. This includes virtual happy hours, team all hands, game nights, and more! You can expect to join a hardworking, collaborative environment and to work with dedicated and team-spirited group of people.

#LI-KO1

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Company

Many of us pursuing work in the biotechnology industry are inspired by a loved one who is living with a disease or the loss of someone in our community. Rare genetic and oncological and immunological diseases not only affect the people living with often debilitating and life-threatening symptoms, but these disorders also significantly impact their families, friends and caregivers.
 
Our researchers work tirelessly to harness the genome editing technology CRISPR/Cas9 for human therapeutic use. Jennifer Doudna, an Intellia co-founder, and Emmanuelle Charpentier were awarded the 2020 Nobel Prize in Chemistry for their pioneering work in CRISPR. We at Intellia are humbled to have a hand in making what we believe to be medical history. As a leader in this space, we take this responsibility to patients seriously.
 
We are employing a modular genome editing platform to create diverse in vivo and ex vivo pipelines, spanning a range of therapeutic indications. Guided by this full-spectrum approach, we are committed to making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to creating novel engineered cell therapies for various cancers and autoimmune diseases.

Change life stories with genome editing therapies!

Stock Symbol: NTLA

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Company info
Website
Phone
(857) 285-6200
Location
40 Erie Street
Cambridge
Massachusetts
02139
United States

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