Vice President, Genome Engineering

Brisbane, CA, United States
May 23, 2021
Science/R&D, Genomics
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Mammoth Biosciences, Inc. is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in Brisbane, CA, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.


Mammoth is seeking a VP of Genome Engineering that will be responsible for driving Mammoth next-generation CRISPR proteins from discovery through preclinical development. The role will involve managing the genome engineering team while also being the main point of contact between external research partners and CROs. The person will work closely with company leadership to set research priorities. A deep understanding of quality, manufacturing and regulatory processes in gene editing is essential.

    • Lead research and pre-clinical development aspects of Mammoth's genome engineering portfolio
    • Lead genome engineering animal studies utilizing Mammoth's CRISPR portfolio
    • Recruit and coach technical team leads to form a strong and cohesive unit
    • Oversee and manage the technical relationships with external partners
    • Work with the business development team to gather, organize, and prioritize R&D efforts
    • Plan and coordinate the creation of new genome engineering modalities
    • Implement project management approaches
    • Project budgeting and scope management
    • Work with operations in the scale up of materials and processes (with external partners as appropriate)
    • Play a strong supporting role in development and maintenance of quality system and regulatory planning
    • Proactively identify potential risks/issues and work with the team to develop mitigation strategies.
    • Work with scientific advisory board and KOLs to refine R&D strategy
    • Act as a "leader as coach" by serving as a mentor to direct reports and other team members and actively giving well intentioned feedback and working with them to highlight their strengths and improve gaps

    • MD or PhD
    • Minimum of 10 years professional experience in the translation of gene therapies or genome engineering technologies
    • Experience leading preclinical development of gene editing or gene therapy product
    • Extensive experience building and managing teams

    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.