Senior Scientist / Scientist, Human Genetics
- Employer
- Maze Therapeutics
- Location
- South San Francisco, CA, United States
- Start date
- May 20, 2021
View more
- Discipline
- Science/R&D, Biotechnology, Genetics
- Required Education
- Bachelors Degree
- Position Type
- Full time
Job Details
We are seeking an exceptional computational biologist/statistical geneticist to join our organization. The successful candidate will contribute to the design of robust genetic association and gene interaction studies, develop workflows/pipelines for association analyses and other statistical genetics techniques, perform analyses on large-scale genetic datasets, integrate results from functional genomics screens with human genetics and contribute to interpretation of results with the goal of identifying new therapeutic targets. Successful candidates will contribute directly to the development of novel disease modifying therapeutics.
Your Role in Navigating The Maze:
- You will work in close collaboration with data science and functional genomics to integrate results from functional genomics studies with human genetics data for new target identification/prioritization
- You will perform and interpret human genetic analyses using public and internal data to identify new targets and therapeutic hypotheses
- You will contribute to writing patents, reports and scientific publications
Your Navigation Tools:
- Ph.D., M.D. or M.D.-Ph.D. with significant relevant experience in bioinformatics/computational biology and the biologic interpretation of human genetic data
- Well versed in the management and analysis of large datasets, including those derived from SNP arrays and next-generation sequencing platforms
- Experience in the analysis of large-scale genomic association studies in complex genetic diseases including correcting for population stratification and imputation of genotypes.
- A strong computational/statistical background (perl, python, R or others) is highly desirable
- Experience with Mendelian Randomization (or other causality inference approaches) or analysis of CRISPR screens is a plus
- Communication skills to clearly present data and your interpretation of the results
Company
Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations.
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.
- Website
- https://mazetx.com/
- Location
-
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States
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