Sr. Research Associate, Pharmaceutical Development

Location
94080, South San Francisco
Posted
May 11, 2021
Required Education
Bachelors Degree
Position Type
Full time

Kezar Life Sciences (NASDAQ: KZR), a clinical-stage biotechnology sciences company located in South San Francisco, is seeking a Sr. Research Associate, Pharmaceutical Development. The position reports to the Scientist, Pharmaceutical Development and will develop preclinical and clinical formulations, and the analytical methods to characterize them, in support of our small molecule immunology and oncology programs. The successful candidate will be part of a dynamic, interdisciplinary team requiring a high degree of creativity and initiative. This is an exciting time to help drive the development of novel therapies for unmet needs in multiple indications.

Kezar is focused on small molecule drug discovery and development to target immune-mediated diseases and cancer. Kezar’s lead product candidate, KZR-616, a selective inhibitor of the immunoproteasome, is being evaluated in Phase 2 clinical trials for the treatment of severe autoimmune diseases. KZR-261, Kezar’s first oncology candidate targeting the protein secretion pathway via the Sec61 translocon, is entering Phase 1 clinical trials in several oncology indications.

RESPONSIBILITIES

  • Develop small molecule HPLC and other analytical methods
  • Participate in small molecule preclinical and clinical formulation design and development
  • Assist in analytical method transfers, drug product manufacturing technology transfers, and other CMO/CRO oversight activities
  • Prepare and characterize formulations for preclinical studies
  • Keep an accurate and detailed electronic laboratory notebook
  • Maintain and troubleshoot laboratory Instruments
  • Additional responsibilities may be added as required

REQUIREMENTS

  • Bachelor’s Degree in Chemistry, Pharmaceutical Sciences, or related field with minimum 2 years Pharmaceutical industry. Master’s Degree in Chemistry, Pharmaceutical Sciences, or related field preferred
  • Proficiency in preparing presentations using PowerPoint
  • Knowledge and understanding of small molecule analytical methods development and qualification/validation
  • Good understanding of basic organic chemistry
  • Expertise in HPLC and other small molecule analytical techniques
  • Pre-formulation and formulation experience. Experience in Parenteral formulations is a plus
  • Very strong problem-solving and troubleshooting skills
  • Technical writing experience such as protocols, reports, and SOPs
  • Ability to communicate complex scientific findings and recommendations in one-on-one discussions, departmental meetings, and written reports
  • Ability to work in a fast paced, dynamic environment with multiple projects, priorities, and personalities