Contract - Scientist I - Formulation/Pharmaceutical Development

Location
San Francisco, CA, United States
Posted
May 03, 2021
Ref
1026
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
CONTRACT - SCIENTIST I - FORMULATION / PHARMACEUTICAL DEVELOPMENT

Position Summary:

Scientist I/II - Formulation/Pharmaceutical Development will help conduct pre-formulation, formulation development, tech transfer and manufacturing activities with the goal of developing robust oral formulations for preclinical and early phase clinical programs.

Essential Duties and Responsibilities:

  • Perform pre-formulation studies such as physico-chemical characterization, pH solubility, excipient compatibility studies etc. and interpret data
  • Develop HPLC analytical methods for early phase programs and execute early phase stability studies for toxicology formulations
  • Design and conduct pre-clinical/toxicology/clinical formulation development activities for various dosage forms
  • Support the pharmaceutical development team with clinical phase drug product formulation development, tech transfer to CMO and GMP manufacturing
  • Manufacture solid dose formulations and characterization using bulk/tap density, hardness, thickness, friability, disintegration and dissolution profiles at GBT
  • Execute statistical design of experiments (DoE) studies to evaluate formulations and process
  • Manage, set up and maintain all the equipment in the formulation lab
  • Maintain inventory of supplies, chemicals and excipients needed for the formulation lab
  • Perform tasks per protocols and develop new protocols as needed
  • Draft reports and present results to colleagues. Other Duties as assigned
  • Approximately 10 - 20% travel may be needed for scientific project management and monitoring of critical project activities


Qualifications:

  • MS with 3-9 years or Ph.D. with 2 - 5 years of experience in pharmaceutical sciences, chemistry, chemical engineering, or related discipline
  • Absolutely require hands-on laboratory experience in pre-formulation, solid-state/physico-chemical, thermal characterization
  • Experience in pharmaceutical unit operations (tablet/capsule granulations, milling, tablet compression, tablet coating etc.)
  • Experience with formulation development of therapeutic agents
  • Independent problem-solving and troubleshooting abilities
  • Excellent data analysis skills with attention to detail and interpretation of results
  • Excellent oral and written communication skills
  • Demonstrated track record of completion of development reports
  • Ability to work independently and in a team environment