Scientific Senior Director, Translational Research
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Senior Director of Translational Research for TME TRC
The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.
The Senior Director, Translational Research will lead the Translational Research groups comprising teams focused on Targeted Oncology, Immuno-Oncology, Stromal Biology, and Translational Core Capabilities (including IHC, next generation sequencing and flow cytometry). You will be responsible for the TME portfolio mechanism of action, disease biology and translational hypothesis support. Your team will provide the relevant translational input to discovery projects as part of interdisciplinary teams comprising research biology, in vivo pharmacology and bioinformatics, with a particular emphasis on human TME biology, to increase the probability of technical success of TME pipeline programs. Working closely with Translational Development colleagues you will also provide translational subject matter expertise and assay support for programs in early clinical development.
Responsible for the scientific leadership and overall effectiveness of the Translational Research group (~25-30 researchers) including providing strategic direction, development and implementation of work efforts within the group, and managing resources within the group, and with external CROs, to meet the department goals.
Responsible for driving translational efforts in preclinical space to identify biomarkers and pharmacodynamic assays that enable development of mechanistically-driven translational packages that incorporate indication/patient selection, assays that will monitor target engagement, and the downstream pathways that impact cancer cell fate.
Responsible for designing, and executing on experiments and data analysis (non-GLP) that form the basis of future GLP clinical translational assays, all in close collaboration with the clinical biomarker leads in the TME TRC Translational Development group.
Responsible for providing core capabilities support (including IHC and NGS) for preclinical programs in support of MoA and model development, including selection and oversight of CROs as needed.
Responsible for fostering a collaborative workplace environment within the direct areas of responsibility and across different groups of stakeholders, on site and across BMS, to meet the TME TRC objectives.
Responsible for direct and indirect management of group of approximately 25-30 people, with responsibility for leading, mentoring and supporting career development.
Responsible for demonstrating leadership consistent with the BMSs people strategy and talent philosophy, including attracting and retaining top key talent critical to business success, developing team members
Responsible for maintaining highest degree of scientific excellence and personal motivation for staff
As part of the TRC leadership team, the incumbent will also be responsible for participating in setting of TME TRC goals, and contributing to, communicating and supporting, all site-wide initiatives to respective department.
Responsible for integrating efforts of the Translational Research group with relevant partners including those both internal and external to RWC and BMS
Responsible for effectively collaborating with other discovery, pharmacology and translational colleagues as well as colleagues in supportive line functions (including integrative and predictive sciences, discovery biotherapeutics, translational medicine, early clinical development and project leadership) to advance preclinical development of therapeutic candidates to early clinical development
Responsible for building relationships and networks outside of direct reporting lines to aid progress of programs and to increase collaborations between Translational Research and other key departments at BMS
Responsible for representing Translational Research group in discussions with external collaborators/companies
Education & Experience:
A PhD (or equivalent) in relevant area of biology with a strong background in immunology, preferably experience in oncology/immune-oncology, and a minimum of 15 years of experience with a focus on translational research in an industry/biotech setting
Proven track record in managing teams of researchers, including the ability to lead others through change by navigating ambiguity, and engaging individuals.
Proven track record in developing and implementing on translational plans to support programs from inception through to clinic, including experience in working with human tissues and in developing clinic-suitable biomarker assays in oncology.
Excellent verbal and written communication skills across all levels both within an organization and with external collaborators/companies with the ability to recognize, articulate, and accept calculated risks to make informed decisions.
Experience with providing oversight into preparation of technical reports and nonclinical sections of documents to support IND filings and other regulatory documents (e.g. laboratory manuals) associated with moving candidates from nonclinical to clinical environment
Comfortable working in a fast-paced environment where speed is paramount.
Ability to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets.
Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, & demonstrated scientific acumen and mechanistic understanding of disease biology.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to firstname.lastname@example.org. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.