Scientist I, Analytical Development

Location
Durham, NC, United States
Posted
May 02, 2021
Ref
1533056
Hotbed
Bio NC
Required Education
Bachelors Degree
Position Type
Full time
The Scientist I, CMC-Analytical Development Gene Therapy Analytics will develop physiochemical methods designed at characterizing and/or measuring the critical quality attributes (CQAs) of cell and gene therapy products. They will be responsible for independently designing and executing laboratory experiments, compiling relevant findings into reports, and presenting results to internal and external stakeholders. A successful candidate will be comfortable working in a dynamic, cross-functional, work environment.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.
  • Development and support of HPLC/UPLC methods (Agilent and Thermo HPLCs/UPLCs; SEC, IEX, and RP using UV, FLR, CAD, and MALS) to measure the CQAs of cell and gene therapy products
  • Development and support of LC-MS/MS methods (Thermo Q Exactive) to characterize the nucleic acid, protein, and/or lipid components of cell and gene therapy products
  • Testing in-process, drug substance, and drug product samples using HPLC and LC-MS/MS
  • Participating in tech transfer protocols to transfer developed methods and acquired knowledge to the Quality Control team
  • Authoring and reviewing analytical test methods, data summaries, protocols, and technical reports
  • Engaging with internal and external stakeholders/customers to set strategic goals, generate workplans, and discuss findings

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Required:
  • PhD in Biochemistry, Analytical Chemistry or a related discipline (or) Masters degree in Biochemistry, Analytical Chemistry or a related discipline with 3+ years of industry experience (or) BS in Biochemistry, Analytical Chemistry or a related discipline with 5+ years of industry experience (or) equivalent combination of education and experience
  • Demonstrated ability to develop HPLC/UPLC and LC-MS/MS methods to characterize or measure the CQAs of in-process, drug substance, and drug product samples
  • Use of excellent oral and written communication skills to present findings to a broader scientific audience and to author technical documents (protocols, reports, and SOPs)
  • Success working in a dynamic, cross-functional environment

Preferred:
  • Experience developing methods for cell and gene therapy products
  • Experience using and maintaining Agilent and Thermo HPLCs/UPLCs and Thermo Q Exactive instruments
  • Experience with the following techniques: ELISA, gel electrophoresis, DLS, DSC, AUC, and capillary electrophoresis (CE-SDS, cLIF, cIEF)

Travel Requirements
  • This position may require up to 10 % travel

Location
  • This is an office-based position located at the main headquarters in downtown Durham, NC.


Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.