Scientist/Senior Scientist, Gene Therapy (AAV)

BridgeBio Gene Therapy, a subsidiary of BridgeBio Pharma, is focused on discovering and developing drugs for patients with grievous genetic diseases. We do this by:

Finding the right starting points to target diseases at their source.

Using a combination of a systematic assessment of the genetic disease landscape and informed diligence on the latest research, we find indications with clear mechanisms of pathogenesis that are ripe for translation into disease-modifying drugs.

Building products with world-class R&D personnel.

We employ industry-leading scientists that work closely with leading academics to prosecute a wide variety of drug programs at the highest level of scientific rigor. Our team combines biopharmaceutical veterans with up-and-coming leaders to drive entrepreneurial thinking grounded by experience.

BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas, including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh with small satellites in other parts of the country.

To learn more, visit us at https://bridgebio.com

Who You Are:

The pre-clinical Scientist will be responsible for technical laboratory activities supporting BridgeBio’s growing gene therapy portfolio. This role is a research, hands-on, and laboratory-based position in our Raleigh, NC laboratory. The incumbent will report to the Head of Virology and Molecular Biology and work closely with other team members to move new therapeutic candidates to clinical evaluation.  In addition, the preclinical Scientist will apply their acquired knowledge, technical competence, and will and skill to learn toward the advancement of BridgeBio’s gene therapy delivery platform.

Responsibilities:

• Support R&D activities by executing in vitro experiments, including design, data analysis, and interpretation, as well as troubleshooting
• Support preclinical development by handling and testing animal samples and rAAV materials provided by CROs, collaborators, and vector production facilities
• Devise novel approaches to advance rAAV as a gene therapy delivery vehicle, including higher productivity and purity, superior potency, enhanced tissue specificity, and reduced cost of goods
• Explore alternatives to rAAV to deliver therapeutic genes to tissues affected by a genetic defect
• Interface closely with other team members, including the CMC department, project management, and document control to ensure on-time completion of tasks
• Assist in the design, development, and qualification of new technical capabilities to assess new and existing lead candidates
• Assist in the authorship of development reports, SOPs, qualification plans and reports, and archiving data

Education, Experience & Skills Requirements:

• Ph.D. in molecular virology with a minimum of 5 years of experience
• MS in molecular virology with a minimum of 8 years of experience
• Experience in molecular virology, including reverse genetics and virus propagation, is required
• Proficiency in recombinant Adeno-Associated Virus (AAV) methods
• Experience with Aseptic tissue culture experience, especially as it pertains to virology
• A strong background in and an appreciation for nucleic acid techniques, including cloning, purification, quantification (real-time and digital PCR), and sequence determination, is a must-have
• Experience in Next-Generation Sequencing is highly desirable
• Coding experience is desirable
• An understanding of protein expression analytical methods (western blot, ELISA, flow cytometry) is a plus
• Attention to detail, meticulous interpretation of scientific data, strong problem-solving skills, and a thorough documentation practice is essential
• Be a team player with strong verbal and non-verbal communication skills displays a healthy level of self-confidence paired with receptiveness to feedback is a good listener with a positive attitude
• The successful candidate will put patients first, let the science speak, think independently, strive for transparency, and be economical in their time management

What We Offer:

• Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
• A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
• Learning and development training to help employees be the best version of themselves
• Collaborative business environment
• Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
• Excellent benefits package
• Flexible PTO
• With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
• A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
• Work with the most productive groups of R&D operators in the industry
• Partnerships with leading institutions
• A platform for meaningful scientific contributions to shine
• Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.