Research Associate, Upstream Process Development

Location
Emeryville, CA
Posted
May 01, 2021
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT is currently conducting three clinical trials: 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for choroideremia and 4D-310 is in a Phase 1/2 clinical trial for Fabry disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

GENERAL SUMMARY:
We seek a talented and passionate Research Associate to join our leading-edge Upstream Process Development team in developing cell culture methods, evaluating new reagents and building platforms for AAV production. This person will report to the head of Upstream Process Development and interact closely with the following teams: Downstream Process Development, Analytical Development and Upstream Manufacturing.
Responsibilities:
  • Lab & Experimental Activities: 80%
  • Design and perform experiments across multiple unit operations including cell expansion, transient plasmid transfection, AAV harvest and sterile filtration.
  • Execute studies that mature process knowledge towards AAV structure/function and improve AAV production yields & product quality.
  • Test, expand and maintain clonal cell lines that can drive process and/or product improvements.
  • Support evaluation of early research candidates through material production and assessment of process robustness.
  • Help evaluate and troubleshoot new technologies as well as continuous improvement projects.
  • Learn the operations of and help execute studies for AAV production in multiple bioreactor systems.
  • Draft and update batch records, electronic lab notebooks (ELN), standard operating procedures and technical reports. Generate technical documentation that is IND-supporting and will be communicated to relevant internal/external stakeholder &/or regulatory parties.
  • Cross-functional & Communication: 20%
  • Collaborate with process & analytical teams to screen, generate and evaluate drug candidates across a range of indications.
  • Contribute to a culture that embraces continuous learning, improvement and innovation. Work with others to expand their technical skill base and deepen their gene therapy expertise.
  • Maintain a current awareness and contribute to current scientific literature; apply new concepts and technologies to our workflow.
  • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Qualifications:
  • Bachelor’s with relevant experience in Bioengineering, Biology, Biochemistry, Life Sciences or related field.    
  • Skills:
  • Asceptic cell culturing is required.
  • Experience with Excel, Word, PowerPoint and similar software.
  • Excellent organizational skills and attention to detail in the lab and with record upkeep.
  • Interest in developing strong communication skills, both written and oral; highlight presentation & communication of ideas in one on one discussions and team meetings.
  • Ability to work independently and in a team environment.
  • Experience working with plasmid sequences is a plus.
  • Working knowledge of GMP & GDP is a plus.
  • Physical Requirements of the Role:
  • In lab and lab support activities may require occasional maneuvering of items approx. 25 lbs during operations and/or storage of consumables.
  • Must be willing to conform with the safety and social distancing practices established by 4DMT as well as the upstream PD group while on-site (4-5 days/week) or in lab (3-4 days/week).

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities